2-Bromo-6-fluoropyridine(CAS: 144100-07-2)

2-Bromo-6-fluoropyridine is a crystalline solid with a molecular weight of approximately 226.03 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. Chemically, it is moderately reactive, particularly with nucleophiles. It can be used as a building block in organic synthesis and as a pharmaceutical intermediate.

2-Bromo-6-fluoropyridine is typically synthesized through the bromination of 6-fluoropyridine with bromine in the presence of a Lewis acid catalyst like iron(III) bromide. The reaction provides a high yield and good selectivity, making it a robust method for preparing this compound.

2-Bromo-6-fluoropyridine is used in the pharmaceutical industry for the synthesis of certain drugs, and in the chemical industry as an intermediate in the production of other compounds. It may also find applications in polymer chemistry and as a sensitizer in semiconductors.

When handling 2-Bromo-6-fluoropyridine, it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate spill kits, and the substance should be stored in a cool, dry place away from direct sunlight. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal instructions.