3-Bromo-8-chloroimidazo[1,2-a]pyrazine

Basic Information

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CAS Number

143591-61-1

Molecular Formula

C6H3BrClN3

Molecular Weight

232.47 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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C1=CN2C(=CN=C2C(=N1)Cl)Br

InChI

InChI=1S/C6H3BrClN3/c7-4-3-10-6-5(8)9-1-2-11(4)6/h1-3H

InChIKey

MCEGPQSPRNOFMG-UHFFFAOYSA-N

LogP

2.1452

Topological Polar Surface Area

30.19 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Complexity

157

Synonyms & References

English

Imidazo[1,2-a]pyrazine, 3-bromo-8-chloro-
3-BROMO-8-CHLOROIMIDAZO[1,2-A]PYRAZINE
AKOS015835766
FT-0648391
MCEGPQSPRNOFMG-UHFFFAOYSA-N
EN300-6777555
W-205594
PB17698
GS-6460
A849231
AC-26552
143591-61-1
SCHEMBL2179909
AM20070312
CS-W019641
Z1269172712
DTXSID10434938
MFCD09909653
3-Bromo-8-chloro-imidazo[1,2-a]pyrazine
SY021874
3-Bromo-8-chloroimidazo[1,2-a]pyrazine
3-bromo-8-chloro-Imidazo[1,2-a]pyrazine
Imidazo[1,2-a]pyrazine,3-bromo-8-chloro-
QC-6
RP05606
FCH1395539
OR300016
AB0022299
Imidazo[1,2-a]pyrazine
3-bromo-8-chloroimidazo[1,2-a]pyrazine

MDL Number

MFCD09909653

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 3-Bromo-8-chloroimidazo[1,2-a]pyrazine (CAS: 143591-61-1)?

3-Bromo-8-chloroimidazo[1,2-a]pyrazine is a crystalline solid with a molecular weight of approximately 257.02 g/mol. It has poor water solubility but is soluble in organic solvents like DMSO and DMF. This compound is known for its high reactivity towards nucleophiles and electrophiles, making it suitable for various synthetic transformations. It decomposes above 200°C.

How is 3-Bromo-8-chloroimidazo[1,2-a]pyrazine (CAS: 143591-61-1) typically synthesized?

3-Bromo-8-chloroimidazo[1,2-a]pyrazine is commonly synthesized via the reaction of 8-chloroimidazo[1,2-a]pyrazine with N-bromosuccinimide (NBS) in the presence of a suitable photoinitiator. This method provides good yields and high regioselectivity. Other synthetic routes involve the use of bromine in the presence of a Lewis acid, leading to the desired product with high purity.

What industries use 3-Bromo-8-chloroimidazo[1,2-a]pyrazine (CAS: 143591-61-1)?

3-Bromo-8-chloroimidazo[1,2-a]pyrazine finds applications in the pharmaceutical industry for its potential as a drug intermediate. It is also used in the development of sensors and in the synthesis of certain polymers. Additionally, it can be utilized in the semiconductor industry for specific chemical treatments.

What precautions should be taken when handling 3-Bromo-8-chloroimidazo[1,2-a]pyrazine (CAS: 143591-61-1)?

When handling 3-Bromo-8-chloroimidazo[1,2-a]pyrazine, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Proper spill control measures must be in place, and the material safety data sheet (MSDS) or SDS should be consulted for detailed information on safe handling and disposal.