2-Bromo-3-methylthiophene

Basic Information

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CAS Number

14282-76-9

Molecular Formula

C5H5BrS

Molecular Weight

177.07 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

Pale-yellow to Yellow-brown Liquid

Boiling Point

176°C

Refractive Index

n20/D 1.572(lit.)

SMILES

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Cc1ccsc1Br

InChI

InChI=1S/C5H5BrS/c1-4-2-3-7-5(4)6/h2-3H,1H3

InChIKey

YYJBWYBULYUKMR-UHFFFAOYSA-N

LogP

2.819020000000001

Topological Polar Surface Area

0.0 Å²

Hydrogen Bond Donor/Acceptor

0 / 0

Complexity

65.1

Safety Information

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GHS Hazard Pictograms

H302

H318

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H318 Causes serious eye damage
Serious eye damage/eye irritation

Hazard Class

Class 6.1 Class 6.1

Sensitiveness

对光敏感

Synonyms & References

English

2-Bromo-3-methylthiophene
2B3MT
Thiophene,2-bromo-3-methyl-
178.04
3-Methyl-2-bromothiophene
2-Bromo-3-methyl-thiophene
2-Brom-3-methyl-thiophen
2-bromo-2-methylthiophene
2-bromo-3-methylthiophen
Thiophene,2-bromo-3-methyl
2-Bromo-3-methylthio
2-bromo-3-methyltiophene
2-Bromo-3-methylthiophene 97%
2-BROMO-3-METHYLTHIOPHENE 98+%
2-Bromo-3-Methylthiophene99.5%
2-bromo-3-methylthiophene

MDL Number

MFCD00059741

Customs Code

2934999090

FAQ

What are the physical and chemical properties of 2-Bromo-3-methylthiophene (CAS: 14282-76-9)?

2-Bromo-3-methylthiophene (CAS: 14282-76-9) is a colorless liquid with a molecular weight of approximately 167.02 g/mol. It has a boiling point of 183-185°C and a melting point of -24°C. The compound is moderately soluble in water but highly soluble in organic solvents. It is chemically reactive towards nucleophiles and can undergo substitution reactions.

How is 2-Bromo-3-methylthiophene (CAS: 14282-76-9) typically synthesized?

2-Bromo-3-methylthiophene (CAS: 14282-76-9) is commonly synthesized via the bromination of 3-methylthiophene using N-bromosuccinimide (NBS) in the presence of a peroxide initiator such as benzoyl peroxide. The reaction is typically carried out in an inert solvent like dichloromethane under reflux conditions, achieving good yield and selectivity.

What industries use 2-Bromo-3-methylthiophene (CAS: 14282-76-9)?

2-Bromo-3-methylthiophene (CAS: 14282-76-9) is used in the pharmaceutical industry for the synthesis of certain intermediates and drug candidates. It also finds applications in the semiconductor industry as a precursor for organic semiconductors. Additionally, it is utilized in the polymer industry for the development of conductive polymers and in the sensor industry for gas sensing applications.

What precautions should be taken when handling 2-Bromo-3-methylthiophene (CAS: 14282-76-9)?

Proper handling of 2-Bromo-3-methylthiophene (CAS: 14282-76-9) requires the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from heat and oxidizing agents. In case of a spill, it should be contained and neutralized using appropriate absorbents. Always refer to the safety data sheet (SDS) for detailed handling and disposal information.