7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-pyrido[2,3-d]pyrimidine-6-carboxamide | CAS No. 142557-61-7
7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-pyrido[2,3-d]pyrimidine-6-carboxamide
Basic Information
CAS Number
142557-61-7
Molecular Formula
C13H15N5O3
Molecular Weight
289.3 g/mol
AD
Chemical Classification
Basic Physical Properties
Density
1.522±0.06 g/cm3 (20 ºC 760 Torr),
Safety Information
View Safety InformationHazard Statement
H301
Toxic if swallowed
Acute toxicity, oral
Acute toxicity, oral
H315
Causes skin irritation
Skin corrosion/irritation
Skin corrosion/irritation
H319
Causes serious eye irritation
Serious eye damage/eye irritation
Serious eye damage/eye irritation
H335
May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation
Synonyms & References
English
- Pyrido[2,3-d]pyrimidine-6-carboxamide, 7-amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxo-
- 7-Amino-1-cyclopropyl-3-ethyl-2,4-dioxopyrido[2,3-d]pyrimidine-6-carboxamide
- 7-Amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide
- A 484954
- A-484954
- Pyrido[2,3-d]pyrimidine-6-carboxamide,7-amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dio...
- Pyrido[2,3-d]pyrimidine-6-carboxamide,7-amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxo-
- 7-AMino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyriMidine-6-carboxaMide
- Kinome_3822
- X5939
- 7-Amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxo-pyrido[2,3-d]pyrimidine-6-carboxamideddd
MDL Number
MFCD22683836
FAQ
What are the physical and chemical properties of 7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-pyrido[2,3-d]pyrimidine-6-carboxamide (CAS: 142557-61-7)?
7-Amino-1-cyclopropyl-3-ethyl-2,4-dioxo-pyrido[2,3-d]pyrimidine-6-carboxamide is a white to off-white solid, with a molecular weight of approximately 318.35 g/mol. It has a high solubility in organic solvents such as DMSO and moderate solubility in water. Chemically, it is highly reactive with nucleophiles, particularly amines and sulfhydryls. It has a pKa of about 4.5 and exhibits good stability under normal conditions but requires handling in a fume hood due to its reactivity.
How is 7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-pyrido[2,3-d]pyrimidine-6-carboxamide (CAS: 142557-61-7) typically synthesized?
7-Amino-1-cyclopropyl-3-ethyl-2,4-dioxo-pyrido[2,3-d]pyrimidine-6-carboxamide can be synthesized via amidation of an appropriately functionalized pyridine derivative with an amine. Commonly, a carbodiimide such as EDCl or DCC is used as a coupling agent, followed by a base like DIPEA. The reaction typically occurs in solvents like DMF or DCM at room temperature, achieving good yields with high selectivity.
What industries use 7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-pyrido[2,3-d]pyrimidine-6-carboxamide (CAS: 142557-61-7)?
7-Amino-1-cyclopropyl-3-ethyl-2,4-dioxo-pyrido[2,3-d]pyrimidine-6-carboxamide finds application primarily in the pharmaceutical industry, where it serves as a potent and selective inhibitor of various enzymes. It is also used in the development of new drug candidates for treating diseases such as cancer and inflammatory conditions. Additionally, it has potential uses in the polymer industry for modifying properties of polymeric materials due to its reactive properties.
What precautions should be taken when handling 7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-pyrido[2,3-d]pyrimidine-6-carboxamide (CAS: 142557-61-7)?
When handling 7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-pyrido[2,3-d]pyrimidine-6-carboxamide, it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and lab coat. Work should be carried out in a well-ventilated fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbent material, and the area should be flushed with water. Always consult the safety data sheet (SDS) for specific handling and disposal instructions.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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