7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-pyrido[2,3-d]pyrimidine-6-carboxamide(CAS: 142557-61-7)

7-Amino-1-cyclopropyl-3-ethyl-2,4-dioxo-pyrido[2,3-d]pyrimidine-6-carboxamide is a white to off-white solid, with a molecular weight of approximately 318.35 g/mol. It has a high solubility in organic solvents such as DMSO and moderate solubility in water. Chemically, it is highly reactive with nucleophiles, particularly amines and sulfhydryls. It has a pKa of about 4.5 and exhibits good stability under normal conditions but requires handling in a fume hood due to its reactivity.

7-Amino-1-cyclopropyl-3-ethyl-2,4-dioxo-pyrido[2,3-d]pyrimidine-6-carboxamide can be synthesized via amidation of an appropriately functionalized pyridine derivative with an amine. Commonly, a carbodiimide such as EDCl or DCC is used as a coupling agent, followed by a base like DIPEA. The reaction typically occurs in solvents like DMF or DCM at room temperature, achieving good yields with high selectivity.

7-Amino-1-cyclopropyl-3-ethyl-2,4-dioxo-pyrido[2,3-d]pyrimidine-6-carboxamide finds application primarily in the pharmaceutical industry, where it serves as a potent and selective inhibitor of various enzymes. It is also used in the development of new drug candidates for treating diseases such as cancer and inflammatory conditions. Additionally, it has potential uses in the polymer industry for modifying properties of polymeric materials due to its reactive properties.

When handling 7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-pyrido[2,3-d]pyrimidine-6-carboxamide, it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and lab coat. Work should be carried out in a well-ventilated fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbent material, and the area should be flushed with water. Always consult the safety data sheet (SDS) for specific handling and disposal instructions.