Adefovir Dipivoxil

Basic Information

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CAS Number

142340-99-6

Molecular Formula

C20H32N5O8P

Molecular Weight

501.48 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Insecticides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Powder

Melting Point

99.0 to 103.0 deg-C

Boiling Point

641°C at 760 mmHg

Density

1.35

Flash Point

341.5±34.3 °C

Solubility

ethanol: soluble50mg/mL

Refractive Index

1.569

SMILES

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CC(C)(C)C(=O)OCOP(=O)(COCCN1C=NC2=C(N=CN=C21)N)OCOC(=O)C(C)(C)C

InChI

InChI=1S/C20H32N5O8P/c1-19(2,3)17(26)30-11-32-34(28,33-12-31-18(27)20(4,5)6)13-29-8-7-25-10-24-14-15(21)22-9-23-16(14)25/h9-10H,7-8,11-13H2,1-6H3,(H2,21,22,23)

InChIKey

WOZSCQDILHKSGG-UHFFFAOYSA-N

LogP

2.7025000000000006

Topological Polar Surface Area

166.98 Å²

Hydrogen Bond Donor/Acceptor

2 / 13

Complexity

706

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Tox21_112243_1
Adefovir dipivoxil- Bio-X
[[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosphonic acid, diester with hydroxymethyl pivalate
Tox21_112243
SMR002530072
DTXSID5046487
[2-(6-aminopurin-9-yl)ethoxymethyl-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate
Adefovir pivoxil (JAN)
9-(2-((-Bis((pivaloyloxy)methoxy)phosphinyl)methoxy)ethyl)adenine
SCHEMBL29729
bis-POM PMEA
Hepsera (TM)
GS-840
AKOS005145737
Bis(POM)-PMEA
Adefovir pivoxil
D01655
'Adefovir Dipivoxil (Preveon, Hepsera)'
9-(2-((Bis((pivaloyloxy)methoxy)phosphinyl)methoxy)ethyl)adenine
Adefovir di(pivaloyloxymethyl) ester
ADEFOVIR DIPIVOXIL [MART.]
Piv2PMEA
A807894
GS-0840
s1718
GS 840
HMS3604F09
9-[2-[Bis(pivaloyloxymethoxy)phosphorylmethoxy]ethyl]adenine
142340-99-6
NCGC00164624-01
Hepsera (TN)

MDL Number

MFCD00869897

FAQ

What is Adefovir Dipivoxil (CAS: 142340-99-6)?

Adefovir Dipivoxil (CAS: 142340-99-6) is a nucleoside analog prodrug used as an antiviral medication. Its chemical formula is C14H22N2O10P, and it appears as a white crystalline powder. It is soluble in water and has a molecular weight of 514.3 g/mol. The compound is designed to improve the bioavailability of adefovir, a potent inhibitor of hepatitis B virus (HBV) replication.

What are the main uses of Adefovir Dipivoxil (CAS: 142340-99-6)?

Adefovir Dipivoxil (CAS: 142340-99-6) is primarily used in pharmaceuticals to treat chronic hepatitis B virus (HBV) infection. It works by inhibiting viral DNA polymerase, reducing viral load. Additionally, it is employed in research for studying antiviral mechanisms and may be used in combination therapies. Its applications are limited to medicinal and scientific contexts.

Is Adefovir Dipivoxil (CAS: 142340-99-6) safe?

Adefovir Dipivoxil (CAS: 142340-99-6) is generally safe when used as prescribed, but it may cause side effects like renal toxicity and lactic acidosis. Handling precautions include wearing gloves and goggles to avoid skin or eye contact. Safety standards such as ICH and EPA guidelines emphasize proper use and monitoring. Always follow medical advice to ensure safe administration.

How should Adefovir Dipivoxil (CAS: 142340-99-6) be stored?

Adefovir Dipivoxil (CAS: 142340-99-6) should be stored in a cool, dry place (20-25°C), protected from light. Maintain low humidity levels to prevent degradation. Keep in a sealed, airtight container to ensure stability. Proper storage is critical to preserve efficacy and safety, as per pharmaceutical guidelines.