Osimertinib Impurity 16

Basic Information

View in Editor

CAS Number

1421372-66-8

Molecular Formula

C25H31N7O

Molecular Weight

445.57 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Boiling Point

676.5±65.0°C at 760 mmHg

SMILES

View in Editor

Cn1cc(c2c1cccc2)c3ccnc(n3)Nc4cc(c(cc4OC)N(C)CCN(C)C)N

InChI

InChI=1S/C25H31N7O/c1-30(2)12-13-31(3)23-15-24(33-5)21(14-19(23)26)29-25-27-11-10-20(28-25)18-16-32(4)22-9-7-6-8-17(18)22/h6-11,14-16H,12-13,26H2,1-5H3,(H,27,28,29)

InChIKey

HTNTZPBKKCORTP-UHFFFAOYSA-N

LogP

3.967500000000002

Topological Polar Surface Area

84.47 Å²

Hydrogen Bond Donor/Acceptor

3 / 8

Complexity

607

Safety Information

View Safety Information

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

Mutated EGFR-IN-1
N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-
AZD9291 Intermediate1
n1-(2-(dimethylamino)ethyl)-5-methoxy-n1-methyl-n4-(4-(1-methyl-1h-indol-3-yl)-2-pyrimidinyl)-1,2,4-benzenetriamine
N1-(2-dimethylaminoethyl)-5-methoxy-N1-methyl-N4-[4-(1-methylindol-3-yl)pyrimidin-2-yl]benzene-1,2,4-triamine
N1-[2-(Dimethylamino)ethyl]-5-methoxy-N1-methyl-N4-[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]-1,2,4-benzenetriamine
AZD9291 intermediates 3
N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,2,4-triamine
N1-[2-(dimethylamino)ethyl]-5-methoxy-N1-methyl-N4-[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]benzene-1,2,4-triamine
AZD9291DA HCl salt
HTNTZPBKKCORTP-UHFFFAOYSA-N
BCP28639

MDL Number

MFCD28167800

FAQ

What is Osimertinib Impurity 16 (CAS: 1421372-66-8)?

Osimertinib Impurity 16 (CAS: 1421372-66-8) is a byproduct of the synthesis of osimertinib, an oral tyrosine kinase inhibitor used in the treatment of certain types of non-small cell lung cancer. It is typically a solid compound with unique physical properties, including solubility and melting point characteristics.

What are the main uses of Osimertinib Impurity 16 (CAS: 1421372-66-8)?

Osimertinib Impurity 16 (CAS: 1421372-66-8) is primarily used as a quality control impurity in the manufacturing process of osimertinib. It helps in assessing the purity and quality of the final product by identifying any impurities present.

Is Osimertinib Impurity 16 (CAS: 1421372-66-8) safe?

Osimertinib Impurity 16 (CAS: 1421372-66-8) is generally considered safe when handled according to standard laboratory procedures. However, appropriate safety precautions, such as wearing gloves and goggles, are essential to prevent skin and eye contact. Avoid inhaling dust or fumes and ensure proper ventilation.

How should Osimertinib Impurity 16 (CAS: 1421372-66-8) be stored?

Osimertinib Impurity 16 (CAS: 1421372-66-8) should be stored in a cool, dry place away from direct sunlight and heat sources. Store it in a tightly sealed container to prevent moisture and dust. Ideal storage conditions are between 15°C to 25°C (59°F to 77°F) with a relative humidity below 60%.