1,3-Thiazole-2-carboxylic acid

Basic Information

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CAS Number

14190-59-1

Molecular Formula

C4H3NO2S

Molecular Weight

129.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

Melting Point

95-118 °C

Boiling Point

310.6°C at 760 mmHg

Density

1.525

Water Solubility

Slightly soluble in water.

Flash Point

141.6℃

Refractive Index

1.617

SMILES

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C1=CSC(=N1)C(=O)O

InChI

InChI=1S/C4H3NO2S/c6-4(7)3-5-1-2-8-3/h1-2H,(H,6,7)

InChIKey

IJVLVRYLIMQVDD-UHFFFAOYSA-N

LogP

0.8412999999999999

Topological Polar Surface Area

50.19 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

106

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

14190-59-1
SY013089
STR04307
SCHEMBL121301
1,3-thiazole-2-carboxylic Acid
Thiazole-2-carboxylic acid
MFCD02094169
DTXSID30376402
IJVLVRYLIMQVDD-UHFFFAOYSA-N
AM20080317
AB10888
FT-0602281
PS-3881
W-201224
CS-W019827
AKOS005169248
BCP23473
A19599
BB 0259709
thiazolecarboxylic acid
thiazole-2-carboxylicacid
AC-22744
EN300-91129
thiazole carboxylic acid
2-THIAZOLECARBOXYLIC ACID
1,3-Thiazole-2-carboxylic acid
RARECHEM AL BE 0750
2-THIAZOLECARBOXYLIC
2-Carboxy-1,3-thiazole
Thiazole-2- forMic acid
thiazol-2-carboxylic acid

MDL Number

MFCD02094169

Customs Code

2934100090

FAQ

What are the physical and chemical properties of 1,3-Thiazole-2-carboxylic acid (CAS: 14190-59-1)?

1,3-Thiazole-2-carboxylic acid is a crystalline solid with a molecular weight of approximately 142.14 g/mol. It has a pKa of around 4.75 and is slightly soluble in water. Chemically, it is reactive towards nucleophiles and can undergo esterification, amide formation, and other acid-base reactions. It is also known for its ability to form complexes with metal ions.

How is 1,3-Thiazole-2-carboxylic acid (CAS: 14190-59-1) typically synthesized?

1,3-Thiazole-2-carboxylic acid can be synthesized via the condensation of thiosemicarbazide with acetic acid. Another method involves the reaction of thiazole with acetic anhydride. These reactions are typically carried out under mild conditions and yield the compound in good to excellent purity.

What industries use 1,3-Thiazole-2-carboxylic acid (CAS: 14190-59-1)?

1,3-Thiazole-2-carboxylic acid finds applications in the pharmaceutical industry due to its antimicrobial and anti-inflammatory properties. It is also used in the production of polymers, sensors, and semiconductors for its structural properties and reactivity.

What precautions should be taken when handling 1,3-Thiazole-2-carboxylic acid (CAS: 14190-59-1)?

Proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn when handling 1,3-Thiazole-2-carboxylic acid. It should be stored in a well-ventilated area and away from oxidizing agents. In case of spills, handle them in a fume hood, and refer to the safety data sheet (SDS) for specific handling instructions.