1,3-Thiazole-2-carboxylic acid(CAS: 14190-59-1)

1,3-Thiazole-2-carboxylic acid is a crystalline solid with a molecular weight of approximately 142.14 g/mol. It has a pKa of around 4.75 and is slightly soluble in water. Chemically, it is reactive towards nucleophiles and can undergo esterification, amide formation, and other acid-base reactions. It is also known for its ability to form complexes with metal ions.

1,3-Thiazole-2-carboxylic acid can be synthesized via the condensation of thiosemicarbazide with acetic acid. Another method involves the reaction of thiazole with acetic anhydride. These reactions are typically carried out under mild conditions and yield the compound in good to excellent purity.

1,3-Thiazole-2-carboxylic acid finds applications in the pharmaceutical industry due to its antimicrobial and anti-inflammatory properties. It is also used in the production of polymers, sensors, and semiconductors for its structural properties and reactivity.

Proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn when handling 1,3-Thiazole-2-carboxylic acid. It should be stored in a well-ventilated area and away from oxidizing agents. In case of spills, handle them in a fume hood, and refer to the safety data sheet (SDS) for specific handling instructions.