Neomycin | CAS No. 1404-04-2

Neomycin

Basic Information

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CAS Number

1404-04-2

Molecular Formula

C23H46N6O13

Molecular Weight

614.64 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Boiling Point

1046.1ºC at 760 mmHg

Density

1.61 g/cm3

Flash Point

586.5ºC

Solubility

H2O: 50 mg/mL As a stock solution. Stock solutions should be filter sterilized and stored at 2-8°C. Stable at 37°C for 5 days.

SMILES

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C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N

InChI

InChI=1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2

InChIKey

PGBHMTALBVVCIT-UHFFFAOYSA-N

LogP

-8.895300000000017

Topological Polar Surface Area

353.10999999999996 Å²

Hydrogen Bond Donor/Acceptor

19 / 19

Complexity

872

Synonyms & References

English

neomycin
CCRIS 5462
Caswell No. 595
EPA Pesticide Chemical Code 006303
Fradiomycin
Fradiomycinum
Myacyne
sulfate (salt)(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside
(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside sulfate (1:1)
(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside
(1R,2S,3R,6R)-3-amino-6-{[(1S,2R,3R,4R,5R)-2-amino-5-(aminomethyl)-3,4-dihydroxycyclohexyl]oxy}-2-hydroxycyclohexyl 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside
(1R,2R,3S,4R,6S)-4,6-diamino-2-({3-O-[(5xi)-2,6-diamino-2,6-dideoxy-alpha-D-xylo-hexopyranosyl]-beta-D-ribofuranosyl}oxy)-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside
(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-D-glucopyranoside sulfate (salt)
NEOMYCIN SULFATE
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neomas
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nivemycin
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Pimavecort

FAQ

What are the physical and chemical properties of Neomycin (CAS: 1404-04-2)?

Neomycin (CAS: 1404-04-2) is a white or off-white crystalline powder. Its molecular weight is approximately 1127.34 g/mol. Neomycin is slightly soluble in water and ethanol. It is unstable in acidic conditions and decomposes readily under alkaline conditions. It is a broad-spectrum antibiotic with significant antibacterial activity.

How is Neomycin (CAS: 1404-04-2) typically synthesized?

Neomycin (CAS: 1404-04-2) is typically synthesized via a fermentation process involving Streptomyces fradiae. The fermentation broth is then extracted and purified through a series of chemical processes including precipitation, filtration, and crystallization. Commonly used solvents and reagents include water, acetic acid, and methanol, with high selectivity and yield for production.

What industries use Neomycin (CAS: 1404-04-2)?

Neomycin (CAS: 1404-04-2) is widely used in the pharmaceutical industry for its antibiotic properties. It is also utilized in the agricultural sector as a feed additive to control bacterial infections in livestock. Additionally, it has applications in the food industry for preserving products and preventing spoilage. In specialized industries, neomycin can be found in wound care products and as an ingredient in some veterinary medications.

What precautions should be taken when handling Neomycin (CAS: 1404-04-2)?

When handling neomycin (CAS: 1404-04-2), it is essential to follow these safety precautions: wear appropriate personal protective equipment (PPE) including gloves, lab coat, and safety goggles. Store it in a cool, dry place, away from direct sunlight and heat sources. Use a fume hood during operations to minimize inhalation risks. In case of a spill, neutralize it with an appropriate chemical and dispose of properly following safety data sheet (SDS) guidelines. Always consult the SDS for detailed safety information.