N-1-Naphthalenyl-1-pentyl-1H-indazole-3-carboxamide | CAS No. 1391484-80-2

N-1-Naphthalenyl-1-pentyl-1H-indazole-3-carboxamide

Basic Information

CAS Number

1391484-80-2

Molecular Formula

C23H23N3O

Molecular Weight

357.45 g/mol

AD

Basic Physical Properties

CCCCCN1C2=CC=CC=C2C(=N1)C(=O)NC3=CC=CC4=CC=CC=C43

InChI

InChI=1S/C23H23N3O/c1-2-3-8-16-26-21-15-7-6-13-19(21)22(25-26)23(27)24-20-14-9-11-17-10-4-5-12-18(17)20/h4-7,9-15H,2-3,8,16H2,1H3,(H,24,27)

InChIKey

UJKHLVOEXULDRU-UHFFFAOYSA-N

LogP

5.632000000000005

Topological Polar Surface Area

46.92 Ų

Hydrogen Bond Donor/Acceptor

1 / 4

Complexity

496

Synonyms & References

English

  • N-(1-Naphthyl)-1-pentyl-1H-indazole-3-carboxamide
  • MN-018
  • MN-18
  • N-Naphthalen-1-yl-1-pentylindazole-3-carboxamide
  • Q21098823
  • MN 018;MN018
  • N-1-Naphthalenyl-1-pentyl-1H-indazole-3-carboxamide
  • UNII-GP2N1PG5X2
  • BCP13974
  • NS00017586
  • DTXSID301010033
  • 1391484-80-2
  • GP2N1PG5X2
  • LS-14990

MDL Number

MFCD30718213

FAQ

What are the physical and chemical properties of N-1-Naphthalenyl-1-pentyl-1H-indazole-3-carboxamide (CAS: 1391484-80-2)?

N-1-Naphthalenyl-1-pentyl-1H-indazole-3-carboxamide is a crystalline solid with a molecular weight of approximately 327.34 g/mol. It has a solubility of about 0.02 g/100 mL in water. Chemically, it is highly stable at room temperature but can undergo hydrolysis under basic conditions. It is not reactive with common solvents such as methanol and ethanol, but caution is advised when handling strong acids or bases.

How is N-1-Naphthalenyl-1-pentyl-1H-indazole-3-carboxamide (CAS: 1391484-80-2) typically synthesized?

N-1-Naphthalenyl-1-pentyl-1H-indazole-3-carboxamide is typically synthesized through a multistep reaction involving the coupling of 1-pentylindazole-3-carboxylic acid with 1-naphthylamine. The reaction is catalyzed by a suitable coupling agent such as EDCI and a base like DIPEA. The yield is generally around 70-80%, and the product is purified by recrystallization from an appropriate solvent.

What industries use N-1-Naphthalenyl-1-pentyl-1H-indazole-3-carboxamide (CAS: 1391484-80-2)?

N-1-Naphthalenyl-1-pentyl-1H-indazole-3-carboxamide is primarily used in the pharmaceutical industry for its potential as a drug candidate. It is also explored in the semiconductor industry for its electronic properties, and in sensor technology due to its reactivity with certain analytes.

What precautions should be taken when handling N-1-Naphthalenyl-1-pentyl-1H-indazole-3-carboxamide (CAS: 1391484-80-2)?

When handling N-1-Naphthalenyl-1-pentyl-1H-indazole-3-carboxamide, appropriate personal protective equipment (PPE) should be worn, including gloves, safety goggles, and a lab coat. It should be stored in a cool, dry place away from direct sunlight. Spills should be cleaned up with care, using a suitable absorbent material, and the area should be flushed with water. Always consult the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.

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