N-1-Naphthalenyl-1-pentyl-1H-indazole-3-carboxamide(CAS: 1391484-80-2)

N-1-Naphthalenyl-1-pentyl-1H-indazole-3-carboxamide is a crystalline solid with a molecular weight of approximately 327.34 g/mol. It has a solubility of about 0.02 g/100 mL in water. Chemically, it is highly stable at room temperature but can undergo hydrolysis under basic conditions. It is not reactive with common solvents such as methanol and ethanol, but caution is advised when handling strong acids or bases.

N-1-Naphthalenyl-1-pentyl-1H-indazole-3-carboxamide is typically synthesized through a multistep reaction involving the coupling of 1-pentylindazole-3-carboxylic acid with 1-naphthylamine. The reaction is catalyzed by a suitable coupling agent such as EDCI and a base like DIPEA. The yield is generally around 70-80%, and the product is purified by recrystallization from an appropriate solvent.

N-1-Naphthalenyl-1-pentyl-1H-indazole-3-carboxamide is primarily used in the pharmaceutical industry for its potential as a drug candidate. It is also explored in the semiconductor industry for its electronic properties, and in sensor technology due to its reactivity with certain analytes.

When handling N-1-Naphthalenyl-1-pentyl-1H-indazole-3-carboxamide, appropriate personal protective equipment (PPE) should be worn, including gloves, safety goggles, and a lab coat. It should be stored in a cool, dry place away from direct sunlight. Spills should be cleaned up with care, using a suitable absorbent material, and the area should be flushed with water. Always consult the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.