3-(5-Methyl-4-phenyl-1,2-oxazol-3-yl)benzenesulfonamide | CAS No. 1373038-56-2

3-(5-Methyl-4-phenyl-1,2-oxazol-3-yl)benzenesulfonamide

Basic Information

CAS Number

1373038-56-2

Molecular Formula

C16H14N2O3S

Molecular Weight

314.37 g/mol

AD

Basic Physical Properties

Cc1c(c(no1)c2cccc(c2)S(=O)(=O)N)c3ccccc3

InChI

InChI=1S/C16H14N2O3S/c1-11-15(12-6-3-2-4-7-12)16(18-21-11)13-8-5-9-14(10-13)22(17,19)20/h2-10H,1H3,(H2,17,19,20)

InChIKey

OIVOENPBZYPLRV-UHFFFAOYSA-N

LogP

2.9644200000000014

Topological Polar Surface Area

86.19 Ų

Hydrogen Bond Donor/Acceptor

2 / 5

Complexity

470

Synonyms & References

English

  • 3-(5-methyl-4-phenyl-3-isoxazolyl)- benzenesulfonamide
  • 3-(5-methyl-4-phenylisoxazol-3-yl)benzenesulfonamide
  • Valdecoxib 3'-Sulfonamide Impurity
  • BCP20775

MDL Number

MFCD30741321

FAQ

What are the physical and chemical properties of 3-(5-Methyl-4-phenyl-1,2-oxazol-3-yl)benzenesulfonamide (CAS: 1373038-56-2)?

3-(5-Methyl-4-phenyl-1,2-oxazol-3-yl)benzenesulfonamide is a crystalline solid with a molecular weight of approximately 326.33 g/mol. It is slightly soluble in water and has good solubility in organic solvents such as methanol and ethanol. Chemically, it is stable and shows limited reactivity under normal conditions. The compound can be characterized by its distinctive UV-Vis absorption spectrum and NMR spectroscopic data.

How is 3-(5-Methyl-4-phenyl-1,2-oxazol-3-yl)benzenesulfonamide (CAS: 1373038-56-2) typically synthesized?

3-(5-Methyl-4-phenyl-1,2-oxazol-3-yl)benzenesulfonamide can be synthesized via a multi-step process involving the reaction of 5-methyl-4-phenyl-1,2-oxazole with phenylsulfamic acid hydrazide. The key steps include the formation of a sulfonamide linkage under basic conditions, followed by purification and crystallization. This compound is often obtained with good yield and selectivity.

What industries use 3-(5-Methyl-4-phenyl-1,2-oxazol-3-yl)benzenesulfonamide (CAS: 1373038-56-2)?

3-(5-Methyl-4-phenyl-1,2-oxazol-3-yl)benzenesulfonamide is used in the pharmaceutical industry for its potential as an intermediate in drug synthesis. It is also explored in polymer science for its functional groups, which can be utilized in various applications. Additionally, it may have applications in sensor technology and semiconductor fabrication processes.

What precautions should be taken when handling 3-(5-Methyl-4-phenyl-1,2-oxazol-3-yl)benzenesulfonamide (CAS: 1373038-56-2)?

When handling 3-(5-Methyl-4-phenyl-1,2-oxazol-3-yl)benzenesulfonamide, it is important to wear appropriate personal protective equipment such as gloves and goggles. Handle in a well-ventilated area or a fume hood. In case of spill, neutralize with an appropriate chemical and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.

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