Voriconazole camphor sulfonate

Basic Information

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CAS Number

137234-71-0

Molecular Formula

C26H30F3N5O5S

Molecular Weight

581.6 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CC(C1=NC=NC=C1F)C(CN2C=NC=N2)(C3=C(C=C(C=C3)F)F)O.CC1(C2CCC1(C(=O)C2)CS(=O)(=O)O)C

InChI

InChI=1S/C16H14F3N5O.C10H16O4S/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18;1-9(2)7-3-4-10(9,8(11)5-7)6-15(12,13)14/h2-5,7-10,25H,6H2,1H3;7H,3-6H2,1-2H3,(H,12,13,14)/t10-,16+;7-,10-/m00/s1

InChIKey

AMYMCJHOGKVJHB-CRFUWKMFSA-N

LogP

3.4465000000000012

Topological Polar Surface Area

148.15999999999997 Å²

Hydrogen Bond Donor/Acceptor

2 / 10

Complexity

852

Synonyms & References

English

4-Pyrimidineethanol, alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-, (alphaR,betaS)-, mono((1R,4S)-7,7-dimethyl-2-oxobicyclo(2.2.1)heptane-1-methanesulfonate)
HY-76200B
4-Pyrimidineethanol, alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-, (alphaR,betaS)-, mono[(1R,4S)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonate]
WQ4A6X26NY
188416-34-4
2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-yl [(1R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl]methanesulfonate
Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1R,4S)-, compd. with (alphaR,betaS)-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol (1:1)
Voriconazole (camphorsulfonate)
DTXSID901019419
UNII-WQ4A6X26NY
Voriconazole camphor sulfonate
137234-71-0
CS-0009541
Voriconazole
2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1h-1,2,4-triazol-1-yl)butan-2-ol
(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-pyrimidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (1R)-10-camphorsulfonate
(2R,3S)-2-(2,4-DIFLUOROPHENYL)-3-(5-FLUOROPYRIMIDIN-4-YL)-1-(1H-1,2,4-TRIAZOL-1-YL)BUTAN-2-OL L-(-)-10-CAMPHORSULFONATE
(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol L(-)-Camphorsulfonate

FAQ

What are the physical and chemical properties of Voriconazole camphor sulfonate (CAS: 137234-71-0)?

Voriconazole camphor sulfonate is crystalline in form with a molecular weight of approximately 804.89 g/mol. It has a low solubility in water (0.5 g/L at 25°C) and higher solubility in organic solvents. Chemically, it is relatively stable but can react with strong bases. It is typically used in pharmaceutical applications.

How is Voriconazole camphor sulfonate (CAS: 137234-71-0) typically synthesized?

Voriconazole camphor sulfonate is synthesized by reacting voriconazole with camphor sulfonic acid. The process involves careful control of pH and temperature to achieve high selectivity and yield. Catalysts such as imidazole or triethylamine are used to enhance the reaction efficiency.

What industries use Voriconazole camphor sulfonate (CAS: 137234-71-0)?

Voriconazole camphor sulfonate is primarily used in the pharmaceutical industry for the treatment of fungal infections. It is also utilized in some polymer-based applications for its antifungal properties.

What precautions should be taken when handling Voriconazole camphor sulfonate (CAS: 137234-71-0)?

When handling Voriconazole camphor sulfonate, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. The substance should be handled in a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information.