3-Hydroxy-N-(2-methoxyphenyl)-2-naphthamide

Basic Information

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CAS Number

135-62-6

Molecular Formula

C18H15NO3

Molecular Weight

293.32 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

161.0 to 166.0 deg-C

Boiling Point

424.1°C at 760 mmHg

Density

1.304g/cm3

Flash Point

210.3ºC

SMILES

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COC1=CC=CC=C1NC(=O)C2=CC3=CC=CC=C3C=C2O

InChI

InChI=1S/C18H15NO3/c1-22-17-9-5-4-8-15(17)19-18(21)14-10-12-6-2-3-7-13(12)11-16(14)20/h2-11,20H,1H3,(H,19,21)

InChIKey

AQYMRQUYPFCXDM-UHFFFAOYSA-N

LogP

3.8063000000000025

Topological Polar Surface Area

58.56 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

387

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H317 May cause an allergic skin reaction
Sensitization, Skin

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

H411 Toxic to aquatic life with long lasting effects
Hazardous to the aquatic environment, long-term hazard

Hazard Class

Class 9 Class 9

Synonyms & References

English

135-62-6
Tox21_301992
Naphthol AS-OL
N-(2-METHOXYPHENYL)-3-HYDROXY-2-NAPHTHAMIDE
3-Hydroxy-2-naphth-o-anisidide
2-Naphth-o-anisidide, 3-hydroxy- (8CI)
Naphtazol F
W-108262
3-Hydroxy-2-naphthoic o-anisidide
A806959
CS-0068352
3-Hydroxy-2'-methoxy-2-naphthanilide
NAPHTHOL OL
Naftolo MOL
2-HYDROXY-3-NAPHTH-O-ANISIDIDE
CAS-135-62-6
NSC50680
DTXSID6038877
Cibanaphthol RK
G9HI0D9DPC
F71196
Naphtanilide OL
Naphtoelan OL
2-Hydroxy-3-naphthoyl-o-anisidide
Kambothol ASOL
Naphthanil OL
H0317
3-Hydroxy-N-(2-methoxyphenyl)-2-naphthamide #
NAFTOL AS-OL
2-Hydroxy-3-Naphthoyl-O-Anisidine
2-(3-Hydroxy-2-naphthamido)anisole

MDL Number

MFCD00021630

Customs Code

2924299090

FAQ

What are the physical and chemical properties of 3-Hydroxy-N-(2-methoxyphenyl)-2-naphthamide (CAS: 135-62-6)?

3-Hydroxy-N-(2-methoxyphenyl)-2-naphthamide (CAS: 135-62-6) is a crystalline solid with a molecular weight of approximately 301.3 g/mol. It is slightly soluble in water and more soluble in organic solvents like ethanol and acetone. This compound exhibits moderate reactivity, particularly in nucleophilic substitution reactions. It has a melting point of around 145-147°C.

How is 3-Hydroxy-N-(2-methoxyphenyl)-2-naphthamide (CAS: 135-62-6) typically synthesized?

3-Hydroxy-N-(2-methoxyphenyl)-2-naphthamide (CAS: 135-62-6) is typically synthesized via a multi-step process starting with naphthaldehyde and methoxybenzaldehyde. The reaction involves condensation followed by an amide formation using an appropriate amine. This method provides high selectivity and good yield, with the final product being purified by recrystallization.

What industries use 3-Hydroxy-N-(2-methoxyphenyl)-2-naphthamide (CAS: 135-62-6)?

3-Hydroxy-N-(2-methoxyphenyl)-2-naphthamide (CAS: 135-62-6) is used in various industries. It finds applications in pharmaceuticals, where it serves as an intermediate in the synthesis of complex molecules. Additionally, it is utilized in the development of sensors and in the production of specialized polymers and semiconductors.

What precautions should be taken when handling 3-Hydroxy-N-(2-methoxyphenyl)-2-naphthamide (CAS: 135-62-6)?

When handling 3-Hydroxy-N-(2-methoxyphenyl)-2-naphthamide (CAS: 135-62-6), it is essential to wear appropriate personal protective equipment (PPE), including goggles, gloves, and a laboratory coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be cleaned up using gloves and a suitable absorbent material, and the area should be thoroughly decontaminated. Always refer to the Safety Data Sheet (SDS) for detailed safety information.