Tetrahydrofolic Acid

Basic Information

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CAS Number

135-16-0

Molecular Formula

C19H23N7O6

Molecular Weight

445.44 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Boiling Point

555.12°C (rough estimate)

Refractive Index

1.6800 (estimate)

SMILES

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C1C(NC2=C(N1)N=C(NC2=O)N)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O

InChI

InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t11?,12-/m0/s1

InChIKey

MSTNYGQPCMXVAQ-KIYNQFGBSA-N

LogP

-0.2819999999999992

Topological Polar Surface Area

211.55999999999997 Å²

Hydrogen Bond Donor/Acceptor

9 / 13

Complexity

834

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Stability

We have observed that this material decomposes steadily over time. Use immediately upon receipt.

Synonyms & References

English

L-GLUTAMIC ACID, N-(4-(((2-AMINO-1,4,5,6,7,8-HEXAHYDRO-4-OXO-6-PTERIDINYL)METHYL)AMINO)BENZOYL)-
CHEMBL91866
tetrahydrofolate
GTPL4675
Q53668656
135-16-0
(2S)-2-(4-((2-amino-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methylamino)benzamido)pentanedioic acid
DTXSID70897520
CHEMBL2021342
L-Tetrahydrofolic Acid (>70% when packaged)
TETRAHYDROFOLICACID
CS-0003422
AKOS040744825
CHEBI:20506
2-{4-[(2-Amino-4-oxo-1,4,5,6,7,8-hexahydro-pteridin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid
(S)-2-{4-[(2-Amino-4-oxo-1,4,5,6,7,8-hexahydro-pteridin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid
N-(4-(((2-Amino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
5,6,7,8-tetrahydrofolic acid
(-)-L-5,6,7,8-TETRAHYDROFOLIC ACID
(2S)-5,6,7,8-tetrahydrofolic acid
HY-14520
L-glutamic acid, N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
Tetrahydrofolic acid, >=65% (when packaged), powder
A910085
Tetrahydropteroylglutamic acid
DB00116
DS-7498
N-[4-{[(2-amino-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}benzoyl]-L-glutamic acid
L-Glutamic acid, N-[4-[[(2-amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
MFCD00135583
CHEBI:68512

MDL Number

MFCD00135583

Customs Code

2933990090

FAQ

What are the physical and chemical properties of Tetrahydrofolic Acid (CAS: 135-16-0)?

Tetrahydrofolic Acid (THFA, CAS: 135-16-0) is a crystalline compound with a molecular weight of approximately 136.13 g/mol. It has a solubility of about 0.1 g per 100 mL in water and is slightly soluble in ethanol. THFA is relatively stable but can react with strong oxidizing agents. It is an important intermediate in organic synthesis and biochemical processes.

How is Tetrahydrofolic Acid (CAS: 135-16-0) typically synthesized?

Tetrahydrofolic Acid (THFA, CAS: 135-16-0) is commonly synthesized via reduction of folic acid using sodium borohydride. This process involves the use of methanol as a solvent, and the reaction yields a high purity product. The reaction is typically carried out in a fume hood to manage any potential inhalation hazards.

What industries use Tetrahydrofolic Acid (CAS: 135-16-0)?

Tetrahydrofolic Acid (THFA, CAS: 135-16-0) is widely used in the pharmaceutical industry for the production of folate supplements and medications. It is also used in the food industry as a fortifying agent. Additionally, THFA has applications in the production of certain polymers and in biochemical research.

What precautions should be taken when handling Tetrahydrofolic Acid (CAS: 135-16-0)?

When handling Tetrahydrofolic Acid (THFA, CAS: 135-16-0), it is important to use personal protective equipment (PPE) such as gloves and goggles. THFA should be stored in a cool, dry place away from direct sunlight. In the event of a spill, immediately clean up the area using appropriate absorbents and dispose of the material according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.