Compound Q&A

How is Tetrahydrofolic Acid (CAS: 135-16-0) typically synthesized?

Answer

Tetrahydrofolic Acid
Tetrahydrofolic Acid (THFA, CAS: 135-16-0) is commonly synthesized via reduction of folic acid using sodium borohydride. This process involves the use of methanol as a solvent, and the reaction yields a high purity product. The reaction is typically carried out in a fume hood to manage any potential inhalation hazards.

About

CAS No 135-16-0
English Name Tetrahydrofolic Acid
Molecular Formula C19H23N7O6
Molecular Weight 445.44 g/mol
SMILES C1C(NC2=C(N1)N=C(NC2=O)N)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
InChIKey MSTNYGQPCMXVAQ-KIYNQFGBSA-N
Last Updated: 2025-10-08 00:58

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