4-Methyl-2(1H)-pyridinone

Basic Information

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CAS Number

13466-41-6

Molecular Formula

C6H7NO

Molecular Weight

109.13 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

130°C

Boiling Point

309°C

Flash Point

186-187°C/12mm

Refractive Index

1.5444 (estimate)

SMILES

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CC1=CC(=O)NC=C1

InChI

InChI=1S/C6H7NO/c1-5-2-3-7-6(8)4-5/h2-4H,1H3,(H,7,8)

InChIKey

YBDRFJXGJQULGH-UHFFFAOYSA-N

LogP

0.6833199999999999

Topological Polar Surface Area

32.86 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

167

Safety Information

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GHS Hazard Pictograms

H315

H319

H335

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

13466-41-6
2(1H)-Pyridone, 4-methyl-
JE7V4GNL8Z
AKOS015842412
4-METHYL-2(1H)-PYRIDONE
AB03735
BP-12688
4-Methyl-2-pyridone
A2865
J-515811
SCHEMBL245430
F8880-7854
CHEBI:194825
NSC-523149
2-Hydroxy-4-methylpyridine (2-Hydroxy-4-picoline)
AS-14953
FT-0691706
2-hydroxy-4-methyl-pyridine
EN300-66899
MFCD00134298
2-Hydroxy-4-methylpyridine
H1052
Hydroxy-4-methylpyridine
YBDRFJXGJQULGH-UHFFFAOYSA-N
4-Methyl-2-pyridinol
FT-0612548
2-hydroxy-4methylpyridine
4-Methyl-2[1H]-pyridone
NSC132870
SY021568
4-methyl-pyridin-2-ol

MDL Number

MFCD00134298

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 4-Methyl-2(1H)-pyridinone (CAS: 13466-41-6)?

4-Methyl-2(1H)-pyridinone is a colorless, clear liquid at room temperature. It has a molecular weight of approximately 123.14 g/mol. This compound is slightly soluble in water but highly soluble in organic solvents such as ethanol, acetone, and dimethylformamide. It is a stable compound but can undergo hydrolysis under basic conditions. It is used as a polar aprotic solvent in organic synthesis and as a reagent for various transformations.

How is 4-Methyl-2(1H)-pyridinone (CAS: 13466-41-6) typically synthesized?

4-Methyl-2(1H)-pyridinone is often synthesized through the reaction of 4-methylpyridine with carbon dioxide in the presence of a Lewis acid catalyst, such as aluminum trichloride. The reaction is typically performed under reflux and yields a mixture of 4-methyl-2(1H)-pyridinone and 4-methyl-3(1H)-pyridinone, with the major product being 4-methyl-2(1H)-pyridinone. The yield is generally around 70-80%.

What industries use 4-Methyl-2(1H)-pyridinone (CAS: 13466-41-6)?

4-Methyl-2(1H)-pyridinone is widely used in the pharmaceutical, polymer, and sensor industries. It serves as a solvent in organic synthesis and as a reagent for various transformations. In the pharmaceutical industry, it is used as a reaction medium for the synthesis of drug candidates. In polymers, it is used as a solvent for polymer solutions and in the preparation of polymer films. It is also utilized in the development of sensors for its solvent properties and stability.

What precautions should be taken when handling 4-Methyl-2(1H)-pyridinone (CAS: 13466-41-6)?

When handling 4-Methyl-2(1H)-pyridinone (CAS: 13466-41-6), appropriate personal protective equipment (PPE) should be worn, including gloves, goggles, and lab coat. It should be handled in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbents, and the area should be rinsed with water. In case of skin contact or inhalation, seek medical attention immediately. Safety data sheets (SDS) should be consulted for detailed information and emergency procedures.