4-Methyl-2(1H)-pyridinone(CAS: 13466-41-6)

4-Methyl-2(1H)-pyridinone is a colorless, clear liquid at room temperature. It has a molecular weight of approximately 123.14 g/mol. This compound is slightly soluble in water but highly soluble in organic solvents such as ethanol, acetone, and dimethylformamide. It is a stable compound but can undergo hydrolysis under basic conditions. It is used as a polar aprotic solvent in organic synthesis and as a reagent for various transformations.

4-Methyl-2(1H)-pyridinone is often synthesized through the reaction of 4-methylpyridine with carbon dioxide in the presence of a Lewis acid catalyst, such as aluminum trichloride. The reaction is typically performed under reflux and yields a mixture of 4-methyl-2(1H)-pyridinone and 4-methyl-3(1H)-pyridinone, with the major product being 4-methyl-2(1H)-pyridinone. The yield is generally around 70-80%.

4-Methyl-2(1H)-pyridinone is widely used in the pharmaceutical, polymer, and sensor industries. It serves as a solvent in organic synthesis and as a reagent for various transformations. In the pharmaceutical industry, it is used as a reaction medium for the synthesis of drug candidates. In polymers, it is used as a solvent for polymer solutions and in the preparation of polymer films. It is also utilized in the development of sensors for its solvent properties and stability.

When handling 4-Methyl-2(1H)-pyridinone (CAS: 13466-41-6), appropriate personal protective equipment (PPE) should be worn, including gloves, goggles, and lab coat. It should be handled in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbents, and the area should be rinsed with water. In case of skin contact or inhalation, seek medical attention immediately. Safety data sheets (SDS) should be consulted for detailed information and emergency procedures.