Compound Q&A
How is 1,4-Dioxaspiro[4.5]dec-8-ylacetic acid (CAS: 134136-04-2) typically synthesized?
Answer
![1,4-Dioxaspiro[4.5]dec-8-ylacetic acid](https://static.chemtradehub.com/structs/134/134136-04-2-8def.webp "1,4-Dioxaspiro[4.5]dec-8-ylacetic acid")
1,4-Dioxaspiro[4.5]dec-8-ylacetic acid is typically synthesized via the condensation of 8-oxa-4,4,9-trimethyl-2,3,6,7-tetrahydroindeno[1,2-c]indol-5(4H)-one with acetic anhydride. The reaction is catalyzed by a transition metal complex, and the yield is around 75%. The process requires mild heating under an inert atmosphere to ensure the formation of the desired product with high selectivity.
About
CAS No
134136-04-2
English Name
1,4-Dioxaspiro[4.5]dec-8-ylacetic acid
Molecular Formula
C10H16O4
Molecular Weight
200.23 g/mol
SMILES
OC(=O)CC1CCC2(CC1)OCCO2
InChIKey
RDZCSTLPRXANJV-UHFFFAOYSA-N
Last Updated: 2026-03-04 21:36
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