1,4-Dioxaspiro[4.5]dec-8-ylacetic acid(CAS: 134136-04-2)

1,4-Dioxaspiro[4.5]dec-8-ylacetic acid is a white crystalline solid with a molecular weight of approximately 236.31 g/mol. It has a solubility of 10.7 g/L in water and is slightly soluble in organic solvents like ethanol and acetone. The compound exhibits weak acidity and can undergo esterification and ester hydrolysis reactions. It is stable under normal conditions but should be stored in a dry place away from moisture and heat.

1,4-Dioxaspiro[4.5]dec-8-ylacetic acid is typically synthesized via the condensation of 8-oxa-4,4,9-trimethyl-2,3,6,7-tetrahydroindeno[1,2-c]indol-5(4H)-one with acetic anhydride. The reaction is catalyzed by a transition metal complex, and the yield is around 75%. The process requires mild heating under an inert atmosphere to ensure the formation of the desired product with high selectivity.

1,4-Dioxaspiro[4.5]dec-8-ylacetic acid is used in the pharmaceutical industry as a precursor for the synthesis of various bioactive compounds. It is also employed in the polymer industry for the development of new materials with specific properties. Additionally, it has applications in sensor technology for detecting specific chemical substances and in the semiconductor industry for use in certain manufacturing processes.

When handling 1,4-Dioxaspiro[4.5]dec-8-ylacetic acid, it is essential to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. It should be handled in a well-ventilated area or a fume hood to minimize exposure to fumes. Spills should be cleaned up immediately using absorbent materials and proper disposal procedures should be followed. Always refer to the safety data sheet (SDS) for detailed handling and storage instructions.