N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-O-(2-methyl-2-propanyl)-L-tyrosine

Basic Information

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CAS Number

133373-24-7

Molecular Formula

C29H31NO5

Molecular Weight

473.57 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Physical State

No data available

Melting Point

186-191 °C

Boiling Point

638.9±55.0 °C at 760 mmHg

Flash Point

340.2±31.5 °C

SMILES

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CC(C)(C)Oc1ccc(cc1)C[C@@H](C(=O)O)N(C)C(=O)OCC2c3ccccc3-c4c2cccc4

InChI

InChI=1S/C29H31NO5/c1-29(2,3)35-20-15-13-19(14-16-20)17-26(27(31)32)30(4)28(33)34-18-25-23-11-7-5-9-21(23)22-10-6-8-12-24(22)25/h5-16,25-26H,17-18H2,1-4H3,(H,31,32)/t26-/m0/s1

InChIKey

WTLSDEYZKFJXFT-SANMLTNESA-N

LogP

5.740500000000005

Topological Polar Surface Area

76.07000000000001 Å²

Hydrogen Bond Donor/Acceptor

1 / 6

Complexity

703

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

Fmoc-N-methyl-O-t-butyl-L-tyrosine
Fmoc-N-Me-Tyr(tBu)-OH
(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-(4-(tert-butoxy)phenyl)propanoic acid
Fmoc-Nalpha-methyl-O-t-butyl-L-tyrosine
(2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-[4-[(2-methylpropan-2-yl)oxy]phenyl]propanoic acid
FMOC-N-METHYL-O-TERT-BUTYL-L-TYROSINE
Fmoc-α-Me-Tyr(tBu)-OH
FMOC-METYR(TBU)-OH
FMOC-L-METYR(TBU)-OH
Fmoc-N-Me-L-Tyr(tBu)-OH
N-FMoc-N-Methyl-O-tert-butyl-L-tyrosine
FMOC-N-ALPHA-METHYL-O-T-BUTYL-L-TYROSINE
(9H-Fluoren-9-yl)MethOxy]Carbonyl N-Me-Tyr(tBu)-OH
Fmoc-N-methyl-O-tert-butyl-L-tyrosine≥ 98% (HPLC)
TMA032
FMOC-beta-HOMO-D-TYR(TBU)-OH
fmoc-N-me-tyr(tbu)-oh, AldrichCPR
fmoc-N-me-tyr(tbu)-oh
FMOC-N-ME-TYR(TBU)-OH
FMOC-N-METHYL-O-T-BUTYL-L-TYROSINE
fMoc-N-Me-tyr(tbu)-oh

MDL Number

MFCD02684471

Customs Code

2922509090

FAQ

What are the physical and chemical properties of N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-O-(2-methyl-2-propanyl)-L-tyrosine (CAS: 133373-24-7)?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-O-(2-methyl-2-propanyl)-L-tyrosine (CAS: 133373-24-7) is a white crystalline solid with a molecular weight of approximately 506.4 g/mol. It has a low solubility in water but is soluble in organic solvents such as methanol and acetonitrile. This compound is relatively stable but can react with strong bases and reducing agents. It is used in synthetic chemistry and biological research due to its unique reactivity and structural features.

How is N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-O-(2-methyl-2-propanyl)-L-tyrosine (CAS: 133373-24-7) typically synthesized?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-O-(2-methyl-2-propanyl)-L-tyrosine (CAS: 133373-24-7) is synthesized through multi-step reactions involving protection, modification, and deprotection of L-tyrosine. Commonly, it involves the use of fluorenylmethoxycarbonyl (Fmoc) protection, followed by selective modifications. The final deprotection yields the desired compound with high yield and selectivity, often achieved with careful control of pH and temperature.

What industries use N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-O-(2-methyl-2-propanyl)-L-tyrosine (CAS: 133373-24-7)?

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-O-(2-methyl-2-propanyl)-L-tyrosine (CAS: 133373-24-7) is primarily used in pharmaceuticals and biotechnology for drug discovery and synthesis of bioactive molecules. It is also relevant in the polymer industry for developing novel materials with specific properties. Due to its unique chemical structure, it plays a crucial role in research and development in these sectors.

What precautions should be taken when handling N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-O-(2-methyl-2-propanyl)-L-tyrosine (CAS: 133373-24-7)?

When handling N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-O-(2-methyl-2-propanyl)-L-tyrosine (CAS: 133373-24-7), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and laboratory coats. Handle it in a well-ventilated fume hood to avoid inhalation risk. Store it in a cool, dark place away from direct sunlight and heat sources. In case of spill, immediately clean up with appropriate absorbent materials and follow proper disposal procedures. Always consult the Safety Data Sheet (SDS) for detailed handling and safety information.