Kanamycin Sulfate

Basic Information

View in Editor

CAS Number

133-92-6

Molecular Formula

C18H38N4O15S

Molecular Weight

582.6 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

250 oC

Boiling Point

943.2 °C at 760 mmHg

Flash Point

524.2 °C

Solubility

H2O: 10-50 mg/mL As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days.

Refractive Index

117.5 ° (C=1, H2O)

SMILES

View in Editor

C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)O)O)OC3C(C(C(C(O3)CO)O)N)O)N.OS(=O)(=O)O

InChI

InChI=1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1

InChIKey

OOYGSFOGFJDDHP-KMCOLRRFSA-N

LogP

-7.944200000000009

Topological Polar Surface Area

357.21 Å²

Hydrogen Bond Donor/Acceptor

17 / 19

Complexity

720

Synonyms & References

English

Kanamycin acid sulfate
D03262
KUC109575AC
D-STREPTAMINE, O-3-AMINO-3-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL(1->6)-O-(6-AMINO-6-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL(1->4))-2-DEOXY-, SULFATE (1:1) (SALT)
Kannasyn
25389-94-0
Q27107073
EN300-19650841
KANAMYCIN SULFATE [VANDF]
HB4429
Kanamycin sulfate Streptomyces kanamyceticus, powder, gamma-irradiated
Kanamycin monosulfate
Ophtalmokalixan
D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl(1->6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl(1->4))-2-deoxy-, sulfate (1:1) (salt)
NS00081901
Kanamycin A sulphate
KANAMYCIN SULFATE [GREEN BOOK]
Kanacedin
NSC-757068
3847-27-6
Kano
HMS500B06
C18H36N4O11 .H2O4S
SCHEMBL65538
KANAMYCIN SULFATE [USP MONOGRAPH]
KANAMYCIN A SULFATE [MI]
D-STREPTAMINE, O-3-AMINO-3-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL(1->6)-O-(6-AMINO-6-DEOXY-.ALPHA.-D-GLUCOPYRANOSYL(1->4))-2-DEOXY-, SULPHATE (1:1) (SALT)
Kanamycin A sulfate
(2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol;sulfuric acid
Cristalomicina
Cantrex

MDL Number

MFCD00070253

FAQ

What are the physical and chemical properties of Kanamycin Sulfate (CAS: 133-92-6)?

Kanamycin Sulfate is a white to off-white crystalline powder with a molecular weight of approximately 1129.52. It is sparingly soluble in water and has limited solubility in ethanol. Chemically, it is highly reactive with bases and can undergo hydrolysis. It is often used in pharmaceutical applications due to its antibacterial properties.

How is Kanamycin Sulfate (CAS: 133-92-6) typically synthesized?

Kanamycin Sulfate is synthesized by a fermentation process followed by chemical modification. The fermentation involves the growth of Streptomyces kanamyceticus, which produces the primary kanamycin compound. This is then converted to kanamycin sulfate through a sulfate esterification process. The synthesis typically requires careful control of pH and temperature to achieve high yield and selectivity.

What industries use Kanamycin Sulfate (CAS: 133-92-6)?

Kanamycin Sulfate is primarily used in the pharmaceutical industry for its antibiotic properties. It is also used in agriculture as a fungicide. Additionally, it has applications in research and development for its biological and chemical properties.

What precautions should be taken when handling Kanamycin Sulfate (CAS: 133-92-6)?

When handling Kanamycin Sulfate, it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up carefully with appropriate absorbent materials. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.