2-(Trifluoromethyl)piperazine

Basic Information

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CAS Number

131922-05-9

Molecular Formula

C5H9F3N2

Molecular Weight

154.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

90-95 °C

Boiling Point

145.1°C at 760 mmHg

Density

1.171

Flash Point

41.5°C

Refractive Index

1.372

SMILES

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C1CNC(CN1)C(F)(F)F

InChI

InChI=1S/C5H9F3N2/c6-5(7,8)4-3-9-1-2-10-4/h4,9-10H,1-3H2

InChIKey

YNEJOOCZWXGXDU-UHFFFAOYSA-N

LogP

0.11009999999999998

Topological Polar Surface Area

24.06 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

112

Safety Information

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Hazard Statement

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

H400 Very toxic to aquatic life
Hazardous to the aquatic environment, acute hazard

Hazard Class

Class 8 Class 8

Sensitiveness

Air Sensitive

Synonyms & References

English

A849545
SCHEMBL18029
MFCD07373382
2-(Trifluoromethyl)piperazine, 95%
FS-2154
C5H9F3N2
EN300-73254
Piperazine, 2-(trifluoromethyl)- (9CI)
131922-05-9
AKOS005255698
AB36961
DTXSID10594369
(+/-)-2-(trifluoromethyl)piperazine
S11290
m-trifluoromethylpiperazine
AB36966
PIPERAZINE, 2-(TRIFLUOROMETHYL)-
CS-W014339
AB36963
2-trifluoromethylpiperazine
2-trifluoromethyl-piperazine
2-(Trifluoromethyl)piperazine
2trifluoromethylpiperazine
AMY18731
2-Trifluoromethyl-Piperazine
(±)-2-(Trifluoromethyl)piperazine
(+/-)-2-(Trifluoromethyl)piperazine
2-(TRIFLUOROMETHYL)-PIPERAZINE
Piperazine,2-(trifluoromethyl)-
(S)-2-TRIFLUOROMETHYL-PIPERAZINE
3-(trifluoromethyl)piperazine

MDL Number

MFCD07373382

FAQ

What are the physical and chemical properties of 2-(Trifluoromethyl)piperazine (CAS: 131922-05-9)?

2-(Trifluoromethyl)piperazine is a colorless or slightly yellow viscous liquid with a molecular weight of approximately 196.07 g/mol. It has a high solubility in water and organic solvents. Chemically, it is a basic compound with strong nucleophilicity, making it reactive towards acids. Its crystalline form is a white solid with a melting point of 53-55°C.

How is 2-(Trifluoromethyl)piperazine (CAS: 131922-05-9) typically synthesized?

2-(Trifluoromethyl)piperazine is typically synthesized through the reaction of 2-chloropiperazine with trifluoroacetic anhydride. The reaction is conducted under anhydrous conditions, and the product is isolated by recrystallization or distillation. The process involves careful temperature control and the use of appropriate catalysts to improve selectivity and yield.

What industries use 2-(Trifluoromethyl)piperazine (CAS: 131922-05-9)?

2-(Trifluoromethyl)piperazine is primarily used in the pharmaceutical industry as a precursor for drug synthesis. It is also used in the polymer industry for functionalization and in the electronics industry for applications in sensors and semiconductors due to its unique electronic properties.

What precautions should be taken when handling 2-(Trifluoromethyl)piperazine (CAS: 131922-05-9)?

Precautions when handling 2-(Trifluoromethyl)piperazine include wearing appropriate personal protective equipment such as gloves, goggles, and lab coats. It should be handled in a well-ventilated area, preferably in a fume hood. Spills should be cleaned up immediately using appropriate absorbents, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.