(4S)-4-Fluoro-D-proline

Basic Information

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CAS Number

131176-02-8

Molecular Formula

C5H8FNO2

Molecular Weight

133.12 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Electronic Chemicals Semiconductor Materials Etchants

Water Treatment Chemicals Coagulants and Flocculants Inorganic Coagulants

Basic Physical Properties

SMILES

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C1C(CNC1C(=O)O)F

InChI

InChI=1S/C5H8FNO2/c6-3-1-4(5(8)9)7-2-3/h3-4,7H,1-2H2,(H,8,9)/t3-,4+/m0/s1

InChIKey

ZIWHMENIDGOELV-IUYQGCFVSA-N

LogP

-0.22900000000000015

Topological Polar Surface Area

49.33 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

128

Synonyms & References

English

AKOS005063934
DTXSID20427477
trans-4-Fluoropyrrolidine-2-carboxylic acid
ZIWHMENIDGOELV-IUYQGCFVSA-N
D-Proline, 4-fluoro-, (4S)-
AMY13641
A26506
CS-0001913
Trans-4-fluoropyrrolidine-2-carboxylic acid hcl
D-Proline, 4-fluoro-, trans-
21156-44-5
trans-4-Fluoro-D-proline
131176-02-8
SCHEMBL900297
(2R-trans)-4-fluoro-2-pyrrolidinecarboxylic acid
AS-34033
EN300-261281
A26504
MFCD07366527
(2R,4S)-4-fluoropyrrolidine-2-carboxylicacid
J-501001
AC-2248
(2R,4S)-4-fluoropyrrolidine-2-carboxylic acid
(2R,4S)-4-Fluoropyrrolidine-2-carboxylic acid
(2R,4S)-4-Fluoro-2-pyrrolidinecarboxylic acid
(2R,4S)-4-fluoropyrrolidinium-2-carboxylate
(4S)-4-Fluor-D-prolin
(4S)-4-Fluoro-D-proline
D-proline, 4-fluoro-, (4S)-
(2R,4S)-4-fluoro-2-proline
(2R,4S)-4-fluoropyrrolidine-2-carboxylic acid hydrochloride

MDL Number

MFCD07366527

FAQ

What are the physical and chemical properties of (4S)-4-Fluoro-D-proline (CAS: 131176-02-8)?

(4S)-4-Fluoro-D-proline is a chiral amino acid derivative. It is a white crystalline solid with a molecular weight of approximately 177.07 g/mol. It is slightly soluble in water but soluble in organic solvents. The compound exhibits moderate reactivity typical of amino acids, particularly in peptide bond formation and derivatization reactions.

How is (4S)-4-Fluoro-D-proline (CAS: 131176-02-8) typically synthesized?

(4S)-4-Fluoro-D-proline can be synthesized via chemical derivatization of D-proline using fluorinating agents such as PFP (pentafluorophenyl trifluoromethanesulfonate) under controlled conditions. Common procedures involve the use of reagents like trifluoromethanesulfonic anhydride to introduce the fluorine substituent, followed by purification and crystallization techniques.

What industries use (4S)-4-Fluoro-D-proline (CAS: 131176-02-8)?

(4S)-4-Fluoro-D-proline is primarily used in the pharmaceutical industry for the synthesis of certain medications. It also finds applications in the polymer industry for the development of special polymers and in the chemical sensor industry for the creation of selective chemical sensors. Additionally, it may be used in research for studying amino acid chemistry and in semiconductor applications for specific chemical functionalities.

What precautions should be taken when handling (4S)-4-Fluoro-D-proline (CAS: 131176-02-8)?

When handling (4S)-4-Fluoro-D-proline, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up carefully using an appropriate solvent, and the area should be thoroughly washed. Always consult the Safety Data Sheet (SDS) for detailed handling and safety instructions.