1-Chloro-4-(2-chloroethoxy)benzene

Basic Information

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CAS Number

13001-28-0

Molecular Formula

C8H8Cl2O

Molecular Weight

191.06 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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C1=CC(=CC=C1OCCCl)Cl

InChI

InChI=1S/C8H8Cl2O/c9-5-6-11-8-3-1-7(10)2-4-8/h1-4H,5-6H2

InChIKey

DFJCCNZMGVNBKQ-UHFFFAOYSA-N

LogP

2.957600000000001

Topological Polar Surface Area

9.23 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

100

Synonyms & References

English

13001-28-0
UNII-F6MPD4B6F9
1-Chloro-4-(2-chloroethoxy)benzene
C72197
2-(4-CHLOROPHENOXY)ETHYL CHLORIDE
DS-12423
Phenol, 4-chloro-O-[2-chloroethyl]-
CS-0196663
DTXSID4074487
F6MPD4B6F9
NS00024083
1-Chloro-4-(2-chloroethoxy)benzene #
4-(2-chloroethoxy)-chlorobenzene
SCHEMBL5824496
4-(2-Chloroethoxy)chlorobenzene
AMY40747
Benzene, 1-chloro-4-(2-chloroethoxy)-
FT-0602650
MFCD03265371
AB13874
AKOS009293755
EINECS 235-833-0
2-chloroethyl 4-chlorophenyl ether
(2-Chlor-aethyl)-(4-chlor-phenyl)-aether
(2-chloro-ethyl)-(4-chloro-phenyl)-ether
1-chloro-4-(2-chloroethoxy)-benzene
4-chloro-(2-chloroethoxy)-benzene
Benzene,1-chloro-4-(2-chloroethoxy)
Phenetole, p,b-dichloro- (6CI,7CI,8CI)
2-Chloroethyl 4-chlorophenyl ether
1-Chloro-4-(chloroethoxy)-benzene

MDL Number

MFCD03265371

Customs Code

2909309090

FAQ

What are the physical and chemical properties of 1-Chloro-4-(2-chloroethoxy)benzene (CAS: 13001-28-0)?

1-Chloro-4-(2-chloroethoxy)benzene is a colorless to pale yellow liquid with a molecular weight of approximately 242.05 g/mol. It has a low solubility in water and is more soluble in organic solvents. This compound is relatively stable under normal conditions but is reactive towards nucleophiles due to the presence of chlorine substituents. It has a density of around 1.098 g/cm³ and a boiling point of about 168°C.

How is 1-Chloro-4-(2-chloroethoxy)benzene (CAS: 13001-28-0) typically synthesized?

1-Chloro-4-(2-chloroethoxy)benzene can be synthesized through the reaction of 4-chloroaniline with 2-chloroethanol in the presence of a base such as potassium carbonate. The reaction involves nucleophilic substitution, yielding a high yield of the target compound. The process is performed under anhydrous conditions to prevent side reactions. The product is purified by recrystallization or distillation.

What industries use 1-Chloro-4-(2-chloroethoxy)benzene (CAS: 13001-28-0)?

1-Chloro-4-(2-chloroethoxy)benzene is primarily used in the pharmaceutical industry for the synthesis of certain active pharmaceutical ingredients. It also finds applications in the polymer industry as a monomer or intermediate. Additionally, it is utilized in the production of chemical sensors and as a precursor in semiconductor manufacturing processes.

What precautions should be taken when handling 1-Chloro-4-(2-chloroethoxy)benzene (CAS: 13001-28-0)?

When handling 1-Chloro-4-(2-chloroethoxy)benzene, safety goggles, gloves, and appropriate personal protective equipment (PPE) should be worn to prevent skin and eye contact. Work should be carried out in a well-ventilated area or a fume hood to minimize inhalation of vapors. In case of a spill, the area should be ventilated and the spill cleaned up using appropriate absorbents. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.