Compound Q&A

How is 1-Chloro-4-(2-chloroethoxy)benzene (CAS: 13001-28-0) typically synthesized?

Answer

1-Chloro-4-(2-chloroethoxy)benzene
1-Chloro-4-(2-chloroethoxy)benzene can be synthesized through the reaction of 4-chloroaniline with 2-chloroethanol in the presence of a base such as potassium carbonate. The reaction involves nucleophilic substitution, yielding a high yield of the target compound. The process is performed under anhydrous conditions to prevent side reactions. The product is purified by recrystallization or distillation.

About

CAS No 13001-28-0
English Name 1-Chloro-4-(2-chloroethoxy)benzene
Molecular Formula C8H8Cl2O
Molecular Weight 191.057 g/mol
SMILES C1=CC(=CC=C1OCCCl)Cl
InChIKey DFJCCNZMGVNBKQ-UHFFFAOYSA-N
Last Updated: 2025-11-07 19:01

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