1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-prolyl-L-proline

Basic Information

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CAS Number

129223-22-9

Molecular Formula

C25H26N2O5

Molecular Weight

434.49 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

193-196°C

Boiling Point

677.7°C at 760 mmHg

Specific Rotation

-85.1° (c=1 CHCl3)

SMILES

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C1CC(N(C1)C(=O)C2CCCN2C(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35)C(=O)O

InChI

InChI=1S/C25H26N2O5/c28-23(26-13-6-12-22(26)24(29)30)21-11-5-14-27(21)25(31)32-15-20-18-9-3-1-7-16(18)17-8-2-4-10-19(17)20/h1-4,7-10,20-22H,5-6,11-15H2,(H,29,30)/t21-,22-/m0/s1

InChIKey

VRAQFWSWKRNOGU-VXKWHMMOSA-N

LogP

3.475500000000002

Topological Polar Surface Area

87.15000000000002 Å²

Hydrogen Bond Donor/Acceptor

1 / 7

Complexity

720

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

129223-22-9
Fmoc-Pro-Pro-OH
(2S)-1-[(2S)-1-(9H-fluoren-9-ylmethoxycarbonyl)pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid
Fmoc-Pro-Pro
(2S)-1-[(2S)-1-[(9H-fluoren-9-ylmethoxy)carbonyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid
VRAQFWSWKRNOGU-VXKWHMMOSA-N
Fmoc-L-Pro-L-Pro-OH
AKOS016842366
DTXSID30456415
L-Proline, 1-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-prolyl-
AMY13578
(2S)-1-[(2S)-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid
J-005660
(S)-1-((S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxylic aci
AC-8988
MFCD00237673
CS-W022730
(S)-1-((S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxylic acid
HY-W041990
l-proline,1-(1-((9h-fluoren-9-ylmethoxy)carbonyl)-l-prolyl)-
C25H26N2O5
DS-1374
N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-prolinyl-L-proline
Fmoc-Prolinyl-proline
N-Fmoc-L-prolyl-L-proline
Fmoc-ProlylProline-OH
Fmoc-Prolinyl-proline (S,S)
(9H-Fluoren-9-yl)MethOxy]Carbonyl Pro-Pro-OH
(S)-1-((S)-1-(((9H-Fluoren-9-yl)Methoxy)carbonyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxylic acid
Fmoc-Pro-Pro-OH99%

MDL Number

MFCD00237673

FAQ

What regulatory guidelines apply to 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-prolyl-L-proline (CAS: 129223-22-9)?

The compound 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-prolyl-L-proline (CAS: 129223-22-9) falls under the scope of the REACH regulations for chemicals in the European Union, which requires registration, evaluation, and authorization. Additionally, it should comply with the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), and may require specific handling and storage as per local regulations. For FDA and EPA related requirements, it is important to consult the latest guidelines and regulations applicable in the United States.

Are there alternatives to 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-prolyl-L-proline (CAS: 129223-22-9) in synthesis?

While 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-prolyl-L-proline (CAS: 129223-22-9) is used in certain synthetic processes, there are alternatives such as other protected amino acids or related fluorenylmethoxycarbonyl (Fmoc) protected compounds. Commonly, triisopropylsilylethyl (TIPS) or tert-butyldiphenylsilyl (BzTrt) may be used as alternative protecting groups in peptide synthesis. These alternatives offer similar functionalities but with different reactivity profiles.

What is the market or research trend for 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-prolyl-L-proline (CAS: 129223-22-9)?

The market for 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-prolyl-L-proline (CAS: 129223-22-9) is primarily driven by its application in peptide synthesis and pharmaceutical research. Recent trends show growing interest in the development of new peptide drugs, which are likely to boost demand for this compound. Additionally, there is increasing research into its use in the preparation of medicinal and bioactive peptides, reflecting its importance in both academic and industrial settings.

How should waste containing 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-prolyl-L-proline (CAS: 129223-22-9) be handled?

Waste containing 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-prolyl-L-proline (CAS: 129223-22-9) should be collected in appropriate containers and stored under appropriate conditions to minimize environmental impact. The waste should be neutralized if necessary, followed by incineration or professional waste disposal. Disposal must comply with local and national regulations to prevent contamination of soil, water, and air. Environmental protection measures, such as using protective equipment and ensuring proper ventilation, are crucial during handling and disposal.