(1R,2S)-1-Phenyl-2-(1-pyrrolidinyl)-1-propanol

Basic Information

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CAS Number

127641-25-2

Molecular Formula

C13H19NO

Molecular Weight

205.3 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Melting Point

45-48 °C

Boiling Point

321.3±22.0 °C at 760 mmHg

Density

1.1±0.1 g/cm3

Flash Point

>230 °F

Refractive Index

1.562

SMILES

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C[C@@H]([C@H](O)c1ccccc1)N2CCCC2

InChI

InChI=1S/C13H19NO/c1-11(14-9-5-6-10-14)13(15)12-7-3-2-4-8-12/h2-4,7-8,11,13,15H,5-6,9-10H2,1H3/t11-,13-/m0/s1

InChIKey

FZVHJGJBJLFWEX-AAEUAGOBSA-N

LogP

2.2043

Topological Polar Surface Area

23.47 Å²

Hydrogen Bond Donor/Acceptor

1 / 2

Complexity

183

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Synonyms & References

English

1-Pyrrolidineethanol, b-methyl-a-phenyl-, (aR,bS)-
(1R,2S)-1-Phenyl-2-(1-pyrrolidinyl)-1-propanol
(1R,2S)-1-Phenyl-2-(1-pyrrolidinyl)propan-1-ol
(1R,2S)-2-Pyrrolidino-1-phenyl-1-propanol
L-psicose
(1S,2R)-N-TOSYLEPHEDRINE
(1R,2S)-(+)-1-phenyl-2-pyrrolidinyl-1-propanol
(1R,2S)-1-phenyl-2-(pyrrolidin-1-yl)-1-propanol
(1R,2S)-1-phenyl-2-pyrrolidi
(1R,2S)-N,N-Tetramethylenenorephedrine
(1R,2S)-N-pyrrolidinylnorephedrine
545481_ALDRICH
ANW-18985
CTK8A9946
N-pyrrolidinylnorephedrine
SureCN597166
(R-(R*,S*))-BETA-METHYL-ALPHA-PHENYL-1-P
(1R,2S)-1-Phenyl-2-pyrrolidin-1-yl-propan-1-ol
(1R,2S)-1-PHENYL-2-(1-PYRROLIDINYL)-1-PROPANOL 98%
(1R,2S)-1-phenyl-2-(pyrrolidin-1-yl)propan-1-ol
WIS9Q321LW
1-Pyrrolidineethanol, beta-methyl-alpha-phenyl-, (alphaR,betaS)-
1-Phenyl-2-(pyrrolidin-1-yl)propan-1-ol, (1R,2S)-
FZVHJGJBJLFWEX-AAEUAGOBSA-N
(1R,2S)-N,N-TETRAMETHYLENENOREPHEDRINE
(1R,2S)-1-PHENYL-2-(1-PYRROLIDINYL)PROPAN-1-OL
(1R,2S)-1-PHENYL-2-(1-PYRROLIDINYL)-1-PROPANOL
1-Pyrrolidineethanol, b-Methyl-a-phenyl-, (aR,bS)-

MDL Number

MFCD01632702

FAQ

What are the physical and chemical properties of (1R,2S)-1-Phenyl-2-(1-pyrrolidinyl)-1-propanol (CAS: 127641-25-2)?

(1R,2S)-1-Phenyl-2-(1-pyrrolidinyl)-1-propanol is a clear, colorless liquid with a molecular weight of approximately 211.27 g/mol. It has a pKa of approximately 11.6. The compound is soluble in organic solvents such as ethanol and acetone, but less soluble in water. It is reactive towards strong acids and bases, and it can undergo substitution reactions.

How is (1R,2S)-1-Phenyl-2-(1-pyrrolidinyl)-1-propanol (CAS: 127641-25-2) typically synthesized?

(1R,2S)-1-Phenyl-2-(1-pyrrolidinyl)-1-propanol is typically synthesized by the reaction of (1R,2S)-1-phenyl-2-hydroxypropan-1-one with 1-pyrrolidinecarboxylate in the presence of a suitable base like sodium hydride or potassium carbonate. The reaction is carried out in an aprotic solvent like dimethylformamide (DMF). The yield can be up to 85% with good selectivity.

What industries use (1R,2S)-1-Phenyl-2-(1-pyrrolidinyl)-1-propanol (CAS: 127641-25-2)?

(1R,2S)-1-Phenyl-2-(1-pyrrolidinyl)-1-propanol is mainly used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is also used in the polymer industry as a monomer or modifier, and in the sensor industry as a sensing component for detecting specific chemicals.

What precautions should be taken when handling (1R,2S)-1-Phenyl-2-(1-pyrrolidinyl)-1-propanol (CAS: 127641-25-2)?

When handling (1R,2S)-1-Phenyl-2-(1-pyrrolidinyl)-1-propanol, it is important to use personal protective equipment (PPE) such as safety goggles, gloves, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight and heat sources. In case of spill, it should be cleaned up carefully following the safety data sheet (SDS) guidelines. Fume hoods should be used when performing reactions involving this compound to avoid inhaling the fumes.