(1R,2S)-1-Phenyl-2-(1-pyrrolidinyl)-1-propanol(CAS: 127641-25-2)

(1R,2S)-1-Phenyl-2-(1-pyrrolidinyl)-1-propanol is a clear, colorless liquid with a molecular weight of approximately 211.27 g/mol. It has a pKa of approximately 11.6. The compound is soluble in organic solvents such as ethanol and acetone, but less soluble in water. It is reactive towards strong acids and bases, and it can undergo substitution reactions.

(1R,2S)-1-Phenyl-2-(1-pyrrolidinyl)-1-propanol is typically synthesized by the reaction of (1R,2S)-1-phenyl-2-hydroxypropan-1-one with 1-pyrrolidinecarboxylate in the presence of a suitable base like sodium hydride or potassium carbonate. The reaction is carried out in an aprotic solvent like dimethylformamide (DMF). The yield can be up to 85% with good selectivity.

(1R,2S)-1-Phenyl-2-(1-pyrrolidinyl)-1-propanol is mainly used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is also used in the polymer industry as a monomer or modifier, and in the sensor industry as a sensing component for detecting specific chemicals.

When handling (1R,2S)-1-Phenyl-2-(1-pyrrolidinyl)-1-propanol, it is important to use personal protective equipment (PPE) such as safety goggles, gloves, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight and heat sources. In case of spill, it should be cleaned up carefully following the safety data sheet (SDS) guidelines. Fume hoods should be used when performing reactions involving this compound to avoid inhaling the fumes.