Oxazol-5-ylmethanol

Basic Information

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CAS Number

127232-41-1

Molecular Formula

C4H5NO2

Molecular Weight

99.09 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Boiling Point

212.8℃ at 760 mmHg

SMILES

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C1=C(OC=N1)CO

InChI

InChI=1S/C4H5NO2/c6-2-4-1-5-3-7-4/h1,3,6H,2H2

InChIKey

CRPXMLXYMBLZEP-UHFFFAOYSA-N

LogP

0.16689999999999994

Topological Polar Surface Area

46.260000000000005 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

57.7

Safety Information

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Hazard Statement

Synonyms & References

English

PB32681
A805664
EN300-135093
BB 0257300
1,3-Oxazol-5-ylmethanol
1,3-OXAZOL-5-METHANOL
J-516353
5-(Hydroxymethyl)-1,3-oxazole
MFCD09027272
PS-9332
AM86088
(1,3-Oxazol-5-yl)methanol
AKOS006345692
5-OXAZOLEMETHANOL
OXAZOLE-5-METHANOL
CRPXMLXYMBLZEP-UHFFFAOYSA-N
BCP16363
Oxazol-5-yl-methanol
FT-0647759
127232-41-1
Oxazol-5-ylmethanol
5-(Hydroxymethyl)oxazole
5-oxazolylmethanol
CS-W003570
SY025391
DTXSID70595998
F9994-5422
oxazole-5-methanol, AldrichCPR
5-Oxazolemethanol
Oxazole-5-methanol
AKOS PAO-1429

MDL Number

MFCD09027272

Customs Code

2934999090

FAQ

What are the physical and chemical properties of Oxazol-5-ylmethanol (CAS: 127232-41-1)?

Oxazol-5-ylmethanol (CAS: 127232-41-1) is a colorless liquid at room temperature with a molecular weight of approximately 118.13 g/mol. It has a pKa of about 8.5, indicating basic properties. The compound is relatively soluble in water and organic solvents. It is moderately reactive, especially in the presence of acids or bases, making it useful in various chemical transformations.

How is Oxazol-5-ylmethanol (CAS: 127232-41-1) typically synthesized?

Oxazol-5-ylmethanol (CAS: 127232-41-1) can be synthesized via the reduction of 5-bromo-methyloxazole using sodium borohydride as the reducing agent. Alternatively, it can be prepared from 5-bromo-methanol through a nucleophilic substitution reaction followed by a Wittig reaction. The yield is typically around 75-85%, and the reaction is stereospecific.

What industries use Oxazol-5-ylmethanol (CAS: 127232-41-1)?

Oxazol-5-ylmethanol (CAS: 127232-41-1) is used in the pharmaceutical industry for the synthesis of drug intermediates. It is also utilized in the polymer industry for the preparation of functionalized polymers. Additionally, it has applications in the semiconductor industry for the development of organic thin-film transistors (OTFTs) and in the sensor industry for its use in gas-sensing applications due to its reactivity with certain gases.

What precautions should be taken when handling Oxazol-5-ylmethanol (CAS: 127232-41-1)?

When handling Oxazol-5-ylmethanol (CAS: 127232-41-1), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be contained and cleaned up using absorbent materials, and it is advisable to consult a safety data sheet (SDS) for specific spill procedures. The compound should be stored in a cool, dry place away from incompatible materials.