Oxazol-5-ylmethanol(CAS: 127232-41-1)

Oxazol-5-ylmethanol (CAS: 127232-41-1) is a colorless liquid at room temperature with a molecular weight of approximately 118.13 g/mol. It has a pKa of about 8.5, indicating basic properties. The compound is relatively soluble in water and organic solvents. It is moderately reactive, especially in the presence of acids or bases, making it useful in various chemical transformations.

Oxazol-5-ylmethanol (CAS: 127232-41-1) can be synthesized via the reduction of 5-bromo-methyloxazole using sodium borohydride as the reducing agent. Alternatively, it can be prepared from 5-bromo-methanol through a nucleophilic substitution reaction followed by a Wittig reaction. The yield is typically around 75-85%, and the reaction is stereospecific.

Oxazol-5-ylmethanol (CAS: 127232-41-1) is used in the pharmaceutical industry for the synthesis of drug intermediates. It is also utilized in the polymer industry for the preparation of functionalized polymers. Additionally, it has applications in the semiconductor industry for the development of organic thin-film transistors (OTFTs) and in the sensor industry for its use in gas-sensing applications due to its reactivity with certain gases.

When handling Oxazol-5-ylmethanol (CAS: 127232-41-1), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be contained and cleaned up using absorbent materials, and it is advisable to consult a safety data sheet (SDS) for specific spill procedures. The compound should be stored in a cool, dry place away from incompatible materials.