(S)-tert-Butyl 5-azaspiro[2.4]heptan-7-ylcarbamate

Basic Information

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CAS Number

127199-45-5

Molecular Formula

C11H20N2O2

Molecular Weight

212.29 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Physical State

White to Yellow Solid

Melting Point

80-84°C

Boiling Point

329.029°C at 760 mmHg

Density

1.099

Flash Point

152.791°C

Refractive Index

1.513

Specific Rotation

-64.9° (c=1, H2O)

SMILES

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CC(C)(C)OC(=O)NC1CNCC12CC2

InChI

InChI=1S/C11H20N2O2/c1-10(2,3)15-9(14)13-8-6-12-7-11(8)4-5-11/h8,12H,4-7H2,1-3H3,(H,13,14)/t8-/m1/s1

InChIKey

CGEBPOMWRHSMLI-MRVPVSSYSA-N

LogP

1.2630999999999997

Topological Polar Surface Area

50.36 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

266

Safety Information

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GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

(S)-tert-Butyl 5-azaspiro[2.4]heptan-7-ylcarbamate
AC-8342
AS-20033
J-502290
CGEBPOMWRHSMLI-MRVPVSSYSA-N
tert-Butyl (7S)-5-azaspiro[2.4]heptan-7-ylcarbamate
tert-butyl N-[(7S)-5-azaspiro[2.4]heptan-7-yl]carbamate
Carbamic acid, N-(7S)-5-azaspiro[2.4]hept-7-yl-, 1,1-dimethylethyl ester
(7S)-5-azaspiro[2.4]hept-7-yl-, 1,1-dimethylethyl ester
7-(S)-tert-Butoxycarbonylamino-5-azaspiro[2.4]heptane
AM85538
7-(S)-[tert-Butoxycarbonylamino]-5-azaspiro[2.4]heptane
tert-butyl (S)-(5-azaspiro[2.4]heptan-7-yl)carbamate
DTXSID40438560
AKOS016842277
BCP10392
7-(S)-t-butoxycarbonylamino-5-azaspiro[2.4]heptane
(7S)-7-tert-butoxycarbonylamino-5-azaspiro(2.4)heptane
(S)-(5-AZA-SPIRO[2.4]HEPT-7-YL)-CARBAMIC ACID TERT-BUTYL ESTER
(S)-7-tert-Butoxycarbonylamino-5-azaspiro[2.4]heptane
(7S)-7-tert-butoxycarbonylamino-5-azaspiro[2.4]heptane
127199-45-5
(S)-7-N-Boc-Amino-5-aza-spiro[2.4]heptane
MFCD09955395
SCHEMBL2738139
(S)-7-(BOC-AMINO)-5-AZASPIRO[2.4]HEPTANE
J-519986
2-Methyl-2-propanyl (7S)-5-azaspiro[2.4]hept-7-ylcarbamate
(S)-7-tert-Butoxycarbonylamino-5-azaspiro[2.4]heptane, AldrichCPR
(S)-(5-Azaspiro[2.4]hept-7-yl)-carbamic acid tert-butyl ester
CS-W005356

MDL Number

MFCD09955395

Customs Code

2942000000

FAQ

What are the physical and chemical properties of (S)-tert-Butyl 5-azaspiro[2.4]heptan-7-ylcarbamate (CAS: 127199-45-5)?

(S)-tert-Butyl 5-azaspiro[2.4]heptan-7-ylcarbamate is a white crystalline solid with a molecular weight of approximately 241.3 g/mol. It is slightly soluble in water but soluble in organic solvents. The compound is known for its reactivity in amide formation and its stability under normal storage conditions.

How is (S)-tert-Butyl 5-azaspiro[2.4]heptan-7-ylcarbamate (CAS: 127199-45-5) typically synthesized?

(S)-tert-Butyl 5-azaspiro[2.4]heptan-7-ylcarbamate can be synthesized through a multi-step process involving the formation of a tert-butyl ester and subsequent conversion to the azaspiro compound via condensation reactions. The synthesis typically involves the use of acylation reagents and is carried out under mild conditions to achieve high yield and selectivity.

What industries use (S)-tert-Butyl 5-azaspiro[2.4]heptan-7-ylcarbamate (CAS: 127199-45-5)?

(S)-tert-Butyl 5-azaspiro[2.4]heptan-7-ylcarbamate is primarily used in the pharmaceutical industry for the synthesis of drugs and intermediates. It is also explored in the polymer industry for its potential applications in the development of functional polymers and materials. Additionally, it has shown promise in the sensor and semiconductor industries for its reactivity and stability.

What precautions should be taken when handling (S)-tert-Butyl 5-azaspiro[2.4]heptan-7-ylcarbamate (CAS: 127199-45-5)?

When handling (S)-tert-Butyl 5-azaspiro[2.4]heptan-7-ylcarbamate, it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be stored in a cool, dry place away from direct sunlight and flammable materials. Spills should be cleaned up using appropriate safety protocols, and the material safety data sheet (SDS) should be consulted for specific handling and disposal instructions.