Acetylvardenafil

Basic Information

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CAS Number

1261351-28-3

Molecular Formula

C25H34N6O3

Molecular Weight

466.59 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CCCC1=NC(=C2N1N=C(NC2=O)C3=C(C=CC(=C3)C(=O)CN4CCN(CC4)CC)OCC)C

InChI

InChI=1S/C25H34N6O3/c1-5-8-22-26-17(4)23-25(33)27-24(28-31(22)23)19-15-18(9-10-21(19)34-7-3)20(32)16-30-13-11-29(6-2)12-14-30/h9-10,15H,5-8,11-14,16H2,1-4H3,(H,27,28,33)

InChIKey

XWSVFUHSNIIXMW-UHFFFAOYSA-N

LogP

2.56442

Topological Polar Surface Area

95.82999999999998 Å²

Hydrogen Bond Donor/Acceptor

1 / 9

Complexity

753

Synonyms & References

English

Vardenafil Acetyl Analogue
2-[2-ethoxy-5-[2-(4-ethylpiperazin-1-yl)acetyl]phenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one
Vardenafil Acetyl An
2-[2-Ethoxy-5-[2-(4-ethyl-1-piperazinyl)acetyl]phenyl]-5-methyl-7-propyl-imidazo[5,1-f][1,2,4]triazin-4(1H)-one
2-(2-Ethoxy-5-(2-(4-ethylpiperazin-1-yl)acetyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one
1261351-28-3
12CRG74917
2-(2-Ethoxy-5-(2-(4-ethyl-1-piperazinyl)acetyl)phenyl)-5-methyl-7-propylimidazo(5,1-f)(1,2,4)triazin-4(1H)-one
J-005335
NS00014943
DTXSID50858558
UNII-12CRG74917
Acetylvardenafil
Imidazo(5,1-f)(1,2,4)triazin-4(1H)-one, 2-(2-ethoxy-5-(2-(4-ethyl-1-piperazinyl)acetyl)phenyl)-5-methyl-7-propyl-
Imidazo[5,1-f][1,2,4]triazin-4(1H)-one, 2-[2-ethoxy-5-[2-(4-ethyl-1-piperazinyl)acetyl]phenyl]-5-methyl-7-propyl-; Acetylvardenafil
CHEBI:228609
Q27251399
2-[2-ethoxy-5-[2-(4-ethylpiperazin-1-yl)acetyl]phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
2-[2-ethoxy-5-[2-(4-ethylpiperazin-1-yl)acetyl]phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-][1,2,4]triazin-4-one
2-{2-Ethoxy-5-[(4-ethylpiperazin-1-yl)acetyl]phenyl}-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one
1ST10840

MDL Number

MFCD19705116

FAQ

What are the physical and chemical properties of Acetylvardenafil (CAS: 1261351-28-3)?

Acetylvardenafil is a crystalline compound with a molecular weight of approximately 519.63 g/mol. It has a melting point around 135°C and is slightly soluble in water. It reacts with acidic and basic compounds and is stable under normal storage conditions. The compound is typically stored at room temperature and away from direct sunlight.

How is Acetylvardenafil (CAS: 1261351-28-3) typically synthesized?

Acetylvardenafil is synthesized through a multi-step reaction involving the acetylation of vardenafil. Commonly, it involves the use of acetic anhydride as the acetylating agent in the presence of a catalyst such as pyridine. The reaction is carried out under anhydrous conditions to ensure high yield and selectivity. The product is purified through recrystallization and further characterized for quality control.

What industries use Acetylvardenafil (CAS: 1261351-28-3)?

Acetylvardenafil is primarily used in the pharmaceutical industry, where it is an active ingredient in erectile dysfunction treatments. It is also used in research for its effects on phosphodiesterases. The compound does not have significant applications in other industries such as polymers, sensors, or semiconductors.

What precautions should be taken when handling Acetylvardenafil (CAS: 1261351-28-3)?

When handling Acetylvardenafil, it is important to wear appropriate personal protective equipment (PPE) such as gloves and goggles. The compound should be used in a well-ventilated area and preferably in a fume hood to avoid inhalation risks. Spills should be handled by sweeping into a waste container, not by sweeping or washing into drains. Refer to the Safety Data Sheet (SDS) for detailed information on handling and storage.