Gilteritinib hemifumarate

Basic Information

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CAS Number

1254053-84-3

Molecular Formula

C62H92N16O10

Molecular Weight

1221.5 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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OC(=O)/C=C/C(=O)O.COc1cc(ccc1N1CCC(CC1)N1CCN(CC1)C)Nc1nc(NC2CCOCC2)c(nc1C(=O)N)CC.COc1cc(ccc1N1CCC(CC1)N1CCN(CC1)C)Nc1nc(NC2CCOCC2)c(nc1C(=O)N)CC

InChI

InChI=1S/2C29H44N8O3.C4H4O4/c2*1-4-23-28(31-20-9-17-40-18-10-20)34-29(26(33-23)27(30)38)32-21-5-6-24(25(19-21)39-3)37-11-7-22(8-12-37)36-15-13-35(2)14-16-36;5-3(6)1-2-4(7)8/h2*5-6,19-20,22H,4,7-18H2,1-3H3,(H2,30,38)(H2,31,32,34);1-2H,(H,5,6)(H,7,8)/b;;2-1+

InChIKey

UJOUWHLYTQFUCU-WXXKFALUSA-N

LogP

5.106200000000012

Topological Polar Surface Area

316.81999999999994 Å²

Hydrogen Bond Donor/Acceptor

10 / 26

Complexity

904

Synonyms & References

English

ASP 2215 hemifumarate
Gilteritinib fumarate
Gilteritinib hemifumarate
5RZZ0Z1GJT
2-Pyrazinecarboxamide, 6-ethyl-3-((3-methoxy-4-(4-(4-methyl-1-piperazinyl)-1-piperidinyl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)-, (2E)-2-butenedioate (2:1)
6-ethyl-3-((3-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carboxamide hemifumarate
Gilteritinib fumarate [USAN]
2-Pyrazinecarbo

MDL Number

MFCD28386208

FAQ

What is Gilteritinib hemifumarate (CAS: 1254053-84-3)?

Gilteritinib hemifumarate is a prodrug that is converted to gilteritinib, an inhibitor of the FLT3 receptor tyrosine kinase. It is used in the treatment of acute myeloid leukemia (AML) with a FLT3 mutation.

What are the main uses of Gilteritinib hemifumarate (CAS: 1254053-84-3)?

Gilteritinib hemifumarate is primarily used in the treatment of patients with acute myeloid leukemia (AML) who have a mutation in the FLT3 gene. It is also used in clinical trials for the treatment of other hematologic malignancies.

Is Gilteritinib hemifumarate (CAS: 1254053-84-3) safe?

Gilteritinib hemifumarate is generally considered safe when used as directed. However, it can cause side effects such as nausea, diarrhea, fatigue, and certain blood disorders. Patients should follow medical advice to minimize risks.

How should Gilteritinib hemifumarate (CAS: 1254053-84-3) be stored?

Gilteritinib hemifumarate should be stored at room temperature (15-30°C) and protected from light. It should be kept in a tightly closed container and away from moisture and heat to maintain its effectiveness and stability.