(2S)-1,1,1-Trifluoro-2-propanamine hydrochloride (1:1)

Basic Information

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CAS Number

125353-44-8

Molecular Formula

C3H7ClF3N

Molecular Weight

149.54 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Specialty Chemicals UV Stabilizers

Electronic Chemicals Semiconductor Materials Etchants

Water Treatment Chemicals Disinfectants Chlorine Compounds

Basic Physical Properties

Boiling Point

116°C at 760 mmHg

Flash Point

23.9°C

SMILES

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CC(C(F)(F)F)N.Cl

InChI

InChI=1S/C3H6F3N.ClH/c1-2(7)3(4,5)6;/h2H,7H2,1H3;1H/t2-;/m0./s1

InChIKey

VLVCERQEOKPRTG-DKWTVANSSA-N

LogP

1.3177

Topological Polar Surface Area

26.02 Å²

Hydrogen Bond Donor/Acceptor

2 / 1

Complexity

57.7

Safety Information

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Hazard Statement

Synonyms & References

English

125353-44-8
(S)-1,1,1-trifluoropropan-2-amine hydrochloride
(2S)-1,1,1-trifluoropropan-2-amine Hydrochloride
(S)-1,1,1-TRIFLUOROPROPAN-2-AMINE HCL
2-Propanamine, 1,1,1-trifluoro-, hydrochloride (1:1), (2S)-
(S)-1,1,1-Trifluoroisopropylamine HCl
SCHEMBL578995
2-Propanamine, 1,1,1-trifluoro-, hydrochloride, (2S)-
AM803120
EN300-216035
(S)-2-Amino-1,1,1-trifluoropropane hydrochloride
MFCD07779094
(S)-1,1,1-TRIFLUOROISOPROPYLAMINEHYDROCHLORIDE
F30469
DTXSID00517966
(S)-1,1,1-Trifluoroisopropylamine hydrochloride
DS-9096
AKOS005063308
(2S)-1,1,1-trifluoropropan-2-amine;hydrochloride
AC-30074
(S)-1,1,1-trifluoropropan-2-aminehydrochloride
CS-0034931
(S)-2,2,2-Trifluoro-1-(methyl)ethylamine hydrochloride
AKOS015894507
BCP28319
(2S)-1,1,1-Trifluoropropan-2-amine--hydrogen chloride (1/1)
(1S)-2,2,2-trifluoro-1-methylethylamine hydrogen chloride
(S)-2-Amino-1,1,1-trifluoropropane Hydrochlorid
(S)-1,1,1-TRIFLUOROISOPROPYLAMINE HYDROCHLORIDE
(S)-2-AMINO-1,1,1-TRIFLUOROPROPANE HYDROCHLORIDE
S-TFIPMHCL

MDL Number

MFCD07779094

FAQ

What are the physical and chemical properties of (2S)-1,1,1-Trifluoro-2-propanamine hydrochloride (CAS: 125353-44-8)?

(2S)-1,1,1-Trifluoro-2-propanamine hydrochloride is a white crystalline solid with a molecular weight of approximately 201.62 g/mol. It has a pKa of about 1.2 and is soluble in water and ethanol. This compound is known for its low reactivity in acidic media but can undergo nucleophilic substitution reactions under certain conditions. It is stable under normal storage conditions but should be protected from strong bases and oxidizing agents.

How is (2S)-1,1,1-Trifluoro-2-propanamine hydrochloride (CAS: 125353-44-8) typically synthesized?

(2S)-1,1,1-Trifluoro-2-propanamine hydrochloride is typically synthesized by the hydrochloric acid treatment of (2S)-1,1,1-trifluoro-2-propanamine. The process involves dissolving the amine in water and adding concentrated hydrochloric acid with stirring. The mixture is then cooled and the precipitate is filtered, washed, and dried. The yield is generally around 75-85%, and the purity can be improved through recrystallization.

What industries use (2S)-1,1,1-Trifluoro-2-propanamine hydrochloride (CAS: 125353-44-8)?

(2S)-1,1,1-Trifluoro-2-propanamine hydrochloride is used in pharmaceuticals for the synthesis of certain drugs and intermediates due to its ability to form stable amine salts. It is also utilized in the polymer industry for the modification of materials and in the production of sensors due to its optical and electronic properties. Some semiconductor applications also benefit from its unique chemical properties.

What precautions should be taken when handling (2S)-1,1,1-Trifluoro-2-propanamine hydrochloride (CAS: 125353-44-8)?

When handling (2S)-1,1,1-Trifluoro-2-propanamine hydrochloride, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. The compound should be stored in a cool, dry place, away from oxidizing agents and strong bases. Handling should be conducted in a fume hood to minimize exposure. In case of a spill, it should be cleaned up immediately using appropriate methods, and the SDS (Safety Data Sheet) should be consulted for detailed procedures.