Compound Q&A

How is (2S)-1,1,1-Trifluoro-2-propanamine hydrochloride (CAS: 125353-44-8) typically synthesized?

Answer

(2S)-1,1,1-Trifluoro-2-propanamine hydrochloride (1:1)
(2S)-1,1,1-Trifluoro-2-propanamine hydrochloride is typically synthesized by the hydrochloric acid treatment of (2S)-1,1,1-trifluoro-2-propanamine. The process involves dissolving the amine in water and adding concentrated hydrochloric acid with stirring. The mixture is then cooled and the precipitate is filtered, washed, and dried. The yield is generally around 75-85%, and the purity can be improved through recrystallization.

About

English Name (2S)-1,1,1-Trifluoro-2-propanamine hydrochloride (1:1)
Molecular Formula C3H7ClF3N
Molecular Weight 149.54 g/mol
SMILES CC(C(F)(F)F)N.Cl
InChIKey VLVCERQEOKPRTG-DKWTVANSSA-N
Last Updated: 2025-10-13 11:18

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