Abemaciclib | CAS No. 1231929-97-7

Abemaciclib

Basic Information

View in Editor

CAS Number

1231929-97-7

Molecular Formula

C27H32F2N8

Molecular Weight

506.61 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Boiling Point

689.3±65.0°C at 760 mmHg

Solubility

Insuluble (1.4E-3 g/L) (25 ºC),

SMILES

View in Editor

CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F

InChI

InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34)

InChIKey

UZWDCWONPYILKI-UHFFFAOYSA-N

LogP

4.936920000000004

Topological Polar Surface Area

75.0 Å²

Hydrogen Bond Donor/Acceptor

1 / 8

Complexity

723

Safety Information

View Safety Information

GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

N-[5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine
CS-1230
[5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-[5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-3H-benzoimidazol-5-yl)-pyrimidin-2-yl]-amine
KB-69638
HY-16297A
LY 2835219 (free base)
LY-2835219 (free base)
2-Pyrimidinamine,N-[5-[(4-ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-
SureCN2487229
LY2835219 free base
Abemaciclib
LY2835219
2-Pyrimidinamine,N-[5-[(4-ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]
6 dual inhibitor
CDK4
LY-2835219 free base
Bemaciclib(LY2835219, abemaciclib)
LY2835219 (free base)
AKOS025404907
Q23901483
Abemaciclib (ly2835219)
1231929-97-7
MFCD22665744
GTPL7382
N-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1H-benzimidazol-6-yl]py
1231929-97-7, Verzenio,
NCGC00351599-06
EX-A1588
Verzenio (TN)
5-(4-ethylpiperazin-1-ylmethyl)pyridin-2-yl)-(5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-3H-benzimidazol-5-yl)pyrimidin-2-yl)amine
LY 2835219

MDL Number

MFCD22665744

FAQ

What is Abemaciclib (CAS: 1231929-97-7)?

Abemaciclib is a selective CDK4/6 inhibitor. It has a chemical formula of C28H28N6O5 and is used in the treatment of certain types of breast cancer in combination with other medications.

What are the main uses of Abemaciclib (CAS: 1231929-97-7)?

Abemaciclib is primarily used in the treatment of hormone receptor-positive, HER2-negative advanced or metastatic breast cancer in combination with fulvestrant. It is also used in certain clinical trials for other types of cancer.

Is Abemaciclib (CAS: 1231929-97-7) safe?

Abemaciclib is generally safe when used as directed. However, it may cause side effects such as diarrhea, fatigue, and neutropenia. Patients should avoid potential interactions with other medications and follow medical advice for monitoring and management of side effects.

How should Abemaciclib (CAS: 1231929-97-7) be stored?

Abemaciclib should be stored at room temperature (15°C to 30°C), away from direct light and moisture. It should be kept in a tightly closed container to protect it from air and light. Avoid storing it in high humidity areas or direct sunlight.