3-Nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]benzenesulfonamide | CAS No. 1228779-96-1
3-Nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]benzenesulfonamide
Basic Information
CAS Number
1228779-96-1
Molecular Formula
C12H17N3O5S
Molecular Weight
315.35 g/mol
AD
Chemical Classification
Basic Physical Properties
Boiling Point
542.0±60.0°C at 760 mmHg
Safety Information
View Safety InformationHazard Statement
H302
Harmful if swallowed
Acute toxicity, oral
Acute toxicity, oral
H315
Causes skin irritation
Skin corrosion/irritation
Skin corrosion/irritation
H319
Causes serious eye irritation
Serious eye damage/eye irritation
Serious eye damage/eye irritation
H335
May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation
Synonyms & References
English
- ABT199 Intermediate 1
- 3-Nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)benzenesulfonamide
- 3-Nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]benzenesulfonamide
- 2,6-Dimethyl-4-(5-nitropyridin-2-yl)morpholine
- 3-?nitro-?4-?[[(tetrahydro-?2H-?pyran-?4-?yl)?methyl]?amino]?Benzenesulfonamide
- 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide
- 3-Nitro-4-[[(tetrahydropyran-4-yl)methyl]amino]benzenesulfonamide
- 3-nitro-4-[(oxan-4-ylmethyl)amino]benzene-1-sulfonamide
- HNQRHNYBVWICKB-UHFFFAOYSA-N
- BCP15140
- SB17744
- AK173680
- Benzenesulfonamide, 3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]-
MDL Number
MFCD28142285
FAQ
What are the physical and chemical properties of 3-Nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]benzenesulfonamide (CAS: 1228779-96-1)?
3-Nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]benzenesulfonamide is a crystalline solid with a molecular weight of approximately 356.14 g/mol. It has a low solubility in water but is more soluble in organic solvents like methanol and acetonitrile. The compound is moderately reactive, particularly with nucleophiles, and exhibits good stability under acidic and basic conditions. It is typically stored in a dry, sealed container away from moisture and light.
How is 3-Nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]benzenesulfonamide (CAS: 1228779-96-1) typically synthesized?
3-Nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]benzenesulfonamide is typically synthesized through a multi-step process involving nitration of a sulfonamide precursor, followed by amination with tetrahydro-2H-pyran-4-ylmethylamine. The reaction is catalyzed by sulfuric acid, and the overall yield is around 75-80%. The reaction requires careful control of temperature and pH to achieve high selectivity and yield.
What industries use 3-Nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]benzenesulfonamide (CAS: 1228779-96-1)?
3-Nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]benzenesulfonamide is primarily used in the pharmaceutical industry for its reactivity and functionality. It can be a key intermediate in the synthesis of various bioactive compounds and drugs. Additionally, it finds applications in the polymer industry for special coatings and sensors. Its reactivity makes it suitable for use in functional polymers and materials with enhanced performance characteristics.
What precautions should be taken when handling 3-Nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]benzenesulfonamide (CAS: 1228779-96-1)?
When handling 3-Nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]benzenesulfonamide, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a fume hood at all times to prevent exposure. Spills should be handled carefully using appropriate absorbents, and the area should be well-ventilated. Always consult the Safety Data Sheet (SDS) for specific handling instructions and emergency procedures. The compound is not considered highly toxic but can cause skin irritation and eye irritation if not handled properly.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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