Compound Q&A
How is 3-Nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]benzenesulfonamide (CAS: 1228779-96-1) typically synthesized?
Answer
![3-Nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]benzenesulfonamide](https://static.chemtradehub.com/structs/122/1228779-96-1-b369.webp "3-Nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]benzenesulfonamide")
3-Nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]benzenesulfonamide is typically synthesized through a multi-step process involving nitration of a sulfonamide precursor, followed by amination with tetrahydro-2H-pyran-4-ylmethylamine. The reaction is catalyzed by sulfuric acid, and the overall yield is around 75-80%. The reaction requires careful control of temperature and pH to achieve high selectivity and yield.
About
CAS No
1228779-96-1
English Name
3-Nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]benzenesulfonamide
Molecular Formula
C12H17N3O5S
Molecular Weight
315.35 g/mol
SMILES
c1cc(c(cc1S(=O)(=O)N)[N+](=O)[O-])NCC2CCOCC2
InChIKey
HNQRHNYBVWICKB-UHFFFAOYSA-N
Last Updated: 2025-10-01 13:51
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