L-Valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline

Basic Information

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CAS Number

122483-84-5

Molecular Formula

C31H45N7O7

Molecular Weight

627.74 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Boiling Point

1065.9±65.0°C at 760 mmHg

Density

1.291

Flash Point

598.5°C

Refractive Index

1.591

SMILES

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CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)O)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C(C(C)C)N

InChI

InChI=1S/C31H45N7O7/c1-5-18(4)26(37-27(40)22(35-28(41)25(32)17(2)3)13-19-8-10-21(39)11-9-19)29(42)36-23(14-20-15-33-16-34-20)30(43)38-12-6-7-24(38)31(44)45/h8-11,15-18,22-26,39H,5-7,12-14,32H2,1-4H3,(H,33,34)(H,35,41)(H,36,42)(H,37,40)(H,44,45)/t18-,22-,23-,24-,25-,26-/m0/s1

InChIKey

DUEUCUPESSMDMI-VVKHCXNMSA-N

LogP

0.4599000000000054

Topological Polar Surface Area

219.84 Å²

Hydrogen Bond Donor/Acceptor

8 / 14

Complexity

1040

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

DTXSID10924182
N-[2-({2-[(2-Amino-1-hydroxy-3-methylbutylidene)amino]-1-hydroxy-3-(4-hydroxyphenyl)propylidene}amino)-1-hydroxy-3-methylpentylidene]histidylproline
Angiotensin I/II (3-7)
BDBM85553
A906708
CS-0198888
C71845
Ang(3-7)
Angiotensin II, 1-de-L-aspartic acid-2-de-L-arginine-5-L-isoleucine-8-de-L-phenylalanine-
l-valyl-l-tyrosyl-l-isoleucyl-l-histidyl-l-proline
MFCD00236787
Angiotensin II (3-7) pentapeptide
A-II-(3-7)
2-6-Angiotensin III,4-L-isoleucine-
(2S)-1-[(2S)-2-[(2S,3S)-2-[(2S)-2-[(2S)-2-amino-3-methylbutanamido]-3-(4-hydroxyphenyl)propanamido]-3-methylpentanamido]-3-(1H-imidazol-4-yl)propanoyl]pyrrolidine-2-carboxylic acid
122483-84-5
AKOS030633008
Val-Tyr-Ile-His-Pro
AS-62152
(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carboxylic acid
Angiotensin II (3-7)
Angiotensin I
H-VAL-TYR-ILE-HIS-PRO-OH
II (3-7)
angiotensinii(3-7
ANGIOTENSIN I/II (3-7)
Angiotensin II(3-7)
(2S)-1-[(2S)-2-[[(

MDL Number

MFCD00236787

FAQ

What are the physical and chemical properties of L-Valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline (CAS: 122483-84-5)?

L-Valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline is a complex peptide with a molecular weight of approximately 1000 Da. It is practically insoluble in water but soluble in organic solvents like methanol and ethanol. The compound is known for its stability and low reactivity under normal conditions, making it suitable for various applications in drug development and biochemistry.

How is L-Valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline (CAS: 122483-84-5) typically synthesized?

L-Valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline is synthesized through solid-phase peptide synthesis using Fmoc chemistry. Commonly, t-Boc protection is used for tyrosine and histidine, and Fmoc for the other amino acids. The peptide is assembled on a solid support, and final deprotection and cleavage yield the desired product with high yield and selectivity.

What industries use L-Valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline (CAS: 122483-84-5)?

L-Valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline is primarily used in the pharmaceutical industry for drug development, particularly in the synthesis of peptide drugs. It is also utilized in biotechnology for protein engineering and in the production of biosensors for medical diagnostics. Additionally, it finds applications in the research and development of new materials and functional polymers.

What precautions should be taken when handling L-Valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline (CAS: 122483-84-5)?

When handling L-Valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline, it is important to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. In the event of a spill, immediately clean up using appropriate absorbent materials, and follow safe disposal procedures as outlined in the Safety Data Sheet (SDS).