L-Valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline(CAS: 122483-84-5)

L-Valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline is a complex peptide with a molecular weight of approximately 1000 Da. It is practically insoluble in water but soluble in organic solvents like methanol and ethanol. The compound is known for its stability and low reactivity under normal conditions, making it suitable for various applications in drug development and biochemistry.

L-Valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline is synthesized through solid-phase peptide synthesis using Fmoc chemistry. Commonly, t-Boc protection is used for tyrosine and histidine, and Fmoc for the other amino acids. The peptide is assembled on a solid support, and final deprotection and cleavage yield the desired product with high yield and selectivity.

L-Valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline is primarily used in the pharmaceutical industry for drug development, particularly in the synthesis of peptide drugs. It is also utilized in biotechnology for protein engineering and in the production of biosensors for medical diagnostics. Additionally, it finds applications in the research and development of new materials and functional polymers.

When handling L-Valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline, it is important to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. In the event of a spill, immediately clean up using appropriate absorbent materials, and follow safe disposal procedures as outlined in the Safety Data Sheet (SDS).