Amylin, human amidated

Basic Information

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CAS Number

122384-88-7

Molecular Formula

C165H261N51O55S2

Molecular Weight

3903.3 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Water Solubility

Soluble to 5 mg/ml in water and in 5% acetic acid.

SMILES

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CCC(C)C(C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CO)C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CC(=O)N)C(=O)NC(C(C)O)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N)NC(=O)C(C)NC(=O)CNC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)N)NC(=O)C(CC(=O)N)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CC3=CN=CN3)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CC(=O)N)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(=O)N)NC(=O)C(C(C)O)NC(=O)C(C)NC(=O)C5CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N5)C(C)O)C)C(C)O)CC(=O)N)NC(=O)C(CCCCN)N

InChI

InChI=1S/C165H261N51O55S2/c1-22-75(12)124(159(266)200-95(47-71(4)5)140(247)203-108(64-219)153(260)206-110(66-221)154(261)216-129(84(21)226)163(270)202-105(58-119(174)234)147(254)209-122(73(8)9)157(264)181-61-121(236)187-106(62-217)150(257)198-103(56-117(172)232)148(255)215-128(83(20)225)162(269)190-93(130(175)237)49-87-38-40-89(227)41-39-87)211-132(239)76(13)183-120(235)60-180-136(243)97(50-85-32-25-23-26-33-85)194-144(251)101(54-115(170)230)196-145(252)102(55-116(171)231)197-151(258)107(63-218)205-152(259)109(65-220)204-142(249)99(52-88-59-178-69-182-88)201-158(265)123(74(10)11)210-146(253)96(48-72(6)7)193-141(248)98(51-86-34-27-24-28-35-86)195-143(250)100(53-114(169)229)191-131(238)77(14)184-139(246)94(46-70(2)3)192-137(244)91(37-31-45-179-165(176)177)188-138(245)92(42-43-113(168)228)189-161(268)126(81(18)223)212-133(240)78(15)185-155(262)111-67-272-273-68-112(207-135(242)90(167)36-29-30-44-166)156(263)199-104(57-118(173)233)149(256)214-125(80(17)222)160(267)186-79(16)134(241)213-127(82(19)224)164(271)208-111/h23-28,32-35,38-41,59,69-84,90-112,122-129,217-227H,22,29-31,36-37,42-58,60-68,166-167H2,1-21H3,(H2,168,228)(H2,169,229)(H2,170,230)(H2,171,231)(H2,172,232)(H2,173,233)(H2,174,234)(H2,175,237)(H,178,182)(H,180,243)(H,181,264)(H,183,235)(H,184,246)(H,185,262)(H,186,267)(H,187,236)(H,188,245)(H,189,268)(H,190,269)(H,191,238)(H,192,244)(H,193,248)(H,194,251)(H,195,250)(H,196,252)(H,197,258)(H,198,257)(H,199,263)(H,200,266)(H,201,265)(H,202,270)(H,203,247)(H,204,249)(H,205,259)(H,206,260)(H,207,242)(H,208,271)(H,209,254)(H,210,253)(H,211,239)(H,212,240)(H,213,241)(H,214,256)(H,215,255)(H,216,261)(H4,176,177,179)

InChIKey

PLOPBXQQPZYQFA-UHFFFAOYSA-N

LogP

-27.33923000000048

Topological Polar Surface Area

1757.4699999999984 Å²

Hydrogen Bond Donor/Acceptor

72 / 106

Complexity

9390

Synonyms & References

English

Pancreatic amylin
Diabetes Associated Peptide Amide human
D02913
FT-0688968
Amlintide (USAN/INN)
122384-88-7
Amylin, human amidated
Diabetes-associated peptide amide human
Amylin (human)
KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY-NH2
Amylin,DAP,IAPP
L-693,403 maleate
LYS-CYS-ASN-THR-ALA-THR-CYS-ALA-THR-GLN-ARG-LEU-ALA-ASN-PHE-LEU-VAL-HIS-SER-SER-ASN-ASN-PHE-GLY-ALA-ILE-LEU-SER-SER-THR-ASN-VAL-GLY-SER-ASN-THR-TYR
LYS-CYS-ASN-THR-ALA-THR-CYS-ALA-THR-GLN-ARG-LEU-ALA-ASN-PHE-LEU-VAL-HIS-SER-SER-ASN-ASN-PHE-GLY-ALA-ILE-LEU-SER-SER-THR-ASN-VAL-GLY-SER-ASN-THR-TYR-NH2(CYS&CYS BRIDGE)
LYS-CYS-ASN-THR-ALA-THR-CYS-ALA-THR-GLN-ARG-LEU-ALA-ASN-PHE-LEU-VAL-HIS-SER-SER-ASN-ASN-PHE-GLY-ALA-ILE-LEU-SER-SER-THR-ASN-VAL-GLY-SER-ASN-THR-TYR-NH2(DISULFIDE BRIDGE:CYS2-CYS7)
DAP
IAPP
Insulinoma or Islet amyloid polypeptide
Human islet amyloid polypeptide
Human islet amyloid polypeptide-NH2
Islet amyloid polypeptide (human)
AMYLIN
AMLINTIDE
Insulinoma
DAP (HUMAN)
IAPP (HUMAN)
Human amylin
AMYLIN, HUMAN
DAP AMIDE, HUMAN
Amylin, amide, human

MDL Number

MFCD00081345

FAQ

What is Amylin, human amidated (CAS: 122384-88-7)?

Amylin, human amidated (CAS: 122384-88-7) is a polypeptide hormone produced in the pancreas. It consists of 30 amino acids and plays a role in glucose homeostasis by inhibiting glucagon secretion and food intake. It has a molecular weight of approximately 3,300 Da and is characterized by its ability to bind to specific receptors on pancreatic beta cells and adipocytes.

What are the main uses of Amylin, human amidated (CAS: 122384-88-7)?

Amylin, human amidated (CAS: 122384-88-7) is primarily used in the treatment of type 2 diabetes. It is often prescribed in combination with other antidiabetic medications to improve blood glucose control. It is also studied for its potential in treating other conditions such as obesity and cardiovascular disease.

Is Amylin, human amidated (CAS: 122388-7) safe?

Amylin, human amidated (CAS: 122384-88-7) is generally considered safe when used as directed under medical supervision. However, as with any medication, it may cause side effects such as hypoglycemia, nausea, and dizziness. It is important to follow healthcare provider instructions and monitor for any adverse reactions.

How should Amylin, human amidated (CAS: 122384-88-7) be stored?

Amylin, human amidated (CAS: 122384-88-7) should be stored in a tightly sealed container at room temperature, between 15-30°C (59-86°F). It should be protected from light and kept out of reach of children. Avoid freezing and vigorous shaking, as this may affect the stability and efficacy of the product. Shelf life is typically 24 months from the date of manufacture if stored under these conditions.