(5E)-Rosiglitazone

Basic Information

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CAS Number

122320-74-5

Molecular Formula

C18H17N3O3S

Molecular Weight

355.4 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

SMILES

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CN(CCOC1=CC=C(C=C1)C=C2C(=O)NC(=O)S2)C3=CC=CC=N3

InChI

InChI=1S/C18H17N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,12H,10-11H2,1H3,(H,20,22,23)/b15-12+

InChIKey

HCDYSWMAMRPMST-NTCAYCPXSA-N

LogP

3.19660

Complexity

518

Synonyms & References

English

(5E)-5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methylidene]-1,3-thiazolidine-2,4-dione
AKOS015900632
2,4-Thiazolidinedione, 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methylene]-
(E)-5-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)benzylidene)thiazolidine-2,4-dione
5-(4-(2-(n-methyl-n-(2-pyridinyl)amino)ethoxy)benzylidene)-2,4-thiazolidinedione
122320-74-5
5-[4-[2-[N-Methyl-N-(2-pyridinyl)amino]ethoxy]-benzylidene]-2,4-thiazolidinedione
5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy] phenyl]methylene]-2,4-thiazolidinedione
5-[4-[2-[N-Methyl-N-(2-pyridinyl)amino]ethoxy]benzylidene]-2,4-thiazolidinedione
Rosiglitazone Related Compound A (25 mg) ((5Z)-5-{[4-({2-[methyl(2-pyridinyl)amino]ethyl}oxy)phenyl]methylidene}-1,3-thiazolidine-2,4-dione)
Rosiglitazone - CAS 155141-29-0
5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYLENE]-2,4- THIAZOLIDINEDIONE
2,4-Thiazolidinedione,5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methylene]
5-(4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzylidene)-2,4-thiazolidinedione
5-[4-[2-(methyl-2-pyridinylamino)ethoxy]benzylidiene]-2,4-thiazolidinedione
5-[4-[2-(N-methyl-N-(2-pyridyl)-amino)ethoxy]benzylidene]thiazolidine-2,4-dione
5-[4-[2-(Methylpyridin-2-ylamino)ethoxy]benzylidene]thiazolidine-2,4-dione
5-[4-[2-(N-Methyl-N-(pyridin-2-yl)amino)ethoxy]benzylidene]thiazolidine-2,4-dione
5-[4-[2-[N-(Methyl)-N-(2-pyridyl)amino]ethoxy]benzylidene]thiazolidine-2,4-dione
5-[[4-[2-[Methyl(pyridin-2-yl)amino]ethoxy]phenyl]methylene]thiazolidine-2,4-dione
5-[4-[N-(METHYL-2-PYRIDINYLAMINO)ETHOXY]BENZYLIDENE-2,4-
5-[4-[N-(Methyl-2-Pyridinylamino)Ethyl]Benylidene]-2,4-Thiazolid-Inedione
5-[4-[2-(N-Methyl-N-2-Pyridyl)Aminoethoxy]Benzyl]-2-Imino-4-Thizaolidinone
5-{4-[2-(N-Methyl-2-pyridyl)aMino]ethoxy}benzylidene}-2,4-thiazolidinedione
5-{4-[2-(Methyl-2-pyridinylamino)-ethoxy]-phenyl}-methylene}-2,4-thiazolidinedio
(5-(4-(2-(N-Methyl-N-(2-pyridinyl)amino)ethoxy)benzylidene)-2,4-thiazolidinedione
5-[[4-[2-[Methyl(pyridin-2-yl)amino]ethoxy]phenyl]methylene] -1,3-thiazolidine- 2,4-dione
5-[(4-{2-[Methyl(pyridin-2-yl)aMino]ethoxy}phenyl)Methylidene]-1,3-thiazolidine-2,4-dione

MDL Number

MFCD07782085

Customs Code

2934999090

FAQ

What is (5E)-Rosiglitazone (CAS: 122320-74-5)?

(5E)-Rosiglitazone, with CAS number 122320-74-5, is a thiazolidinedione antidiabetic drug. It is used to treat type 2 diabetes mellitus. Chemically, it is a derivative of rosiglitazone with a 5E configuration. It exhibits insulin-sensitizing properties by activating peroxisome proliferator-activated receptor gamma (PPAR-γ).

What are the main uses of (5E)-Rosiglitazone (CAS: 122320-74-5)?

(5E)-Rosiglitazone is primarily used to manage type 2 diabetes mellitus. It is an antidiabetic drug that improves glucose metabolism by enhancing insulin sensitivity in adipose tissue, liver, and muscle. This compound is employed in oral formulations for long-term treatment of diabetes.

Is (5E)-Rosiglitazone (CAS: 122320-74-5) safe?

(5E)-Rosiglitazone is generally considered safe when used under medical supervision. However, it can cause side effects such as weight gain, fluid retention, and an increased risk of cardiovascular events. Patients should follow medical advice and regular monitoring to manage potential risks.

How should (5E)-Rosiglitazone (CAS: 122320-74-5) be stored?

(5E)-Rosiglitazone should be stored at room temperature (15°C to 30°C) and protected from light. It should be kept in a tightly closed container to prevent moisture and degradation. Avoid exposure to extreme temperatures and keep out of reach of children and pets.