6-Fluoro-3-iodoimidazo[1,2-a]pyridine

Basic Information

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CAS Number

1219127-01-1

Molecular Formula

C7H4FIN2

Molecular Weight

262.03 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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C1=CC2=NC=C(N2C=C1F)I

InChI

InChI=1S/C7H4FIN2/c8-5-1-2-7-10-3-6(9)11(7)4-5/h1-4H

InChIKey

JQASPOWSYWAGEP-UHFFFAOYSA-N

LogP

2.078

Topological Polar Surface Area

17.3 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

155

Synonyms & References

English

6-Fluoro-3-iodoimidazo[1,2-a]pyridine
6-fluoro-3-iodo-4H-1-benzopyran-4-one
6-Fluoro-3-iodo-4H-benzopyran-4-one
6-Fluoro-3-iodo-4H-chromen-4-one
6-Fluoro-3-iodochromone
6-fluoro-3-iodo-imidazo[1,2-a]pyridine
ACMC-20alyy
CTK8C5809
6-fluoro-3-iodoimidazo[1,2-a]pyridine
DB-219845
IMidazo[1,2-a]pyridine, 6-fluoro-3-iodo-
CS-0092165
1219127-01-1
BH-0704
D75315
MFCD20483025
AKOS016028504
SCHEMBL1355409

MDL Number

MFCD20483025

FAQ

What are the physical and chemical properties of 6-Fluoro-3-iodoimidazo[1,2-a]pyridine (CAS: 1219127-01-1)?

6-Fluoro-3-iodoimidazo[1,2-a]pyridine (CAS: 1219127-01-1) is a crystalline solid with a molecular weight of approximately 258.04 g/mol. It is poorly soluble in water but soluble in organic solvents like dimethylformamide (DMF) and acetonitrile. The compound is known for its high reactivity, particularly towards nucleophiles and electrophiles, and it is often used in medicinal chemistry for its pharmacological potential.

How is 6-Fluoro-3-iodoimidazo[1,2-a]pyridine (CAS: 1219127-01-1) typically synthesized?

6-Fluoro-3-iodoimidazo[1,2-a]pyridine (CAS: 1219127-01-1) is usually synthesized via the iodination of 6-fluorimidazo[1,2-a]pyridine using N-iodosuccinimide (NIS) in the presence of a palladium catalyst. The reaction involves a Suzuki-Miyaura coupling and typically yields a high purity product with good selectivity and yield under optimized conditions.

What industries use 6-Fluoro-3-iodoimidazo[1,2-a]pyridine (CAS: 1219127-01-1)?

6-Fluoro-3-iodoimidazo[1,2-a]pyridine (CAS: 1219127-01-1) is primarily used in the pharmaceutical industry for drug development, particularly in the synthesis of novel antitumor and antiviral agents. It also finds applications in semiconductor manufacturing as a precursor for the production of functional materials with unique electronic properties.

What precautions should be taken when handling 6-Fluoro-3-iodoimidazo[1,2-a]pyridine (CAS: 1219127-01-1)?

When handling 6-Fluoro-3-iodoimidazo[1,2-a]pyridine (CAS: 1219127-01-1), it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. The substance should be used in a well-ventilated area or a fume hood to prevent inhalation of fumes. Spills should be handled with caution, and the material safety data sheet (MSDS) should be consulted for detailed spill cleanup procedures. Storage should be in a cool, dry place away from direct sunlight and flammable materials.