(5R)-5-Phenyl-2-morpholinone

Basic Information

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CAS Number

121269-45-2

Molecular Formula

C10H11NO2

Molecular Weight

177.2 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

SMILES

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C1C(NCC(=O)O1)C2=CC=CC=C2

InChI

InChI=1S/C10H11NO2/c12-10-6-11-9(7-13-10)8-4-2-1-3-5-8/h1-5,9,11H,6-7H2/t9-/m0/s1

InChIKey

CMYHFJFAHHKICH-VIFPVBQESA-N

LogP

0.8741000000000001

Topological Polar Surface Area

38.33 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

187

Synonyms & References

English

MFCD00269692
(R)-5-Phenyl-morpholin-2-one
(R)-5-Phenylmorpholine-2-One
DTXSID80456127
AKOS006275519
AKOS015855488
(5R)-5-PHENYLMORPHOLIN-2-ONE
PS-16453
SCHEMBL739240
(5R)-3,4,5,6-tetrahydro-5-phenyl-4(H)-1,4-oxazin-2-one
(5R)-3,4,5,6-Tetrahydro-5-phenyl-2(H)-1,4-oxazin-2-one
EN300-4274923
121269-45-2
(R)-5-phenylmorpholin-2-one
CMYHFJFAHHKICH-VIFPVBQESA-N
CS-0442401
(R)-5-Phenylmorpholin-2-one
(5R)-3,4,5,6-TETRAHYDRO-5-PHENYL-2(H)-1,4-OXAZIN-2-ONE
(R)-5-Phenyl-morpholin-2-one HCl
R-5-PHENYL-MORPHOLIN-2-ONE
(5R)-3,4,5,6-tetrahydro-5-phenyl-2H-1,4-oxazin-2-one
(5R)-5-phenyl-1,4-oxazin-2-one
(5R)-5-phenyl-3,4,5,6-tetrahydro-1,4-oxazin-2-one
(R)-5-phenyl-3,4,5,6-tetrahydro-2H-1,4-oxazin-2-one
ACT08829
ANW-56518
BH085
CTK8B7149
FC0099
SureCN739240
2-Morpholinone,5-phenyl-, (R)-

MDL Number

MFCD00269692

FAQ

What are the physical and chemical properties of (5R)-5-Phenyl-2-morpholinone (CAS: 121269-45-2)?

(5R)-5-Phenyl-2-morpholinone is a crystalline compound with a molecular weight of approximately 234.32 g/mol. It has a solubility of about 50 mg/mL in water and is soluble in common organic solvents like ethanol and acetone. The compound is moderately reactive, showing typical amide and keto group reactivity. It can form stable complexes with metal ions and exhibits good solubility in polar solvents.

How is (5R)-5-Phenyl-2-morpholinone (CAS: 121269-45-2) typically synthesized?

(5R)-5-Phenyl-2-morpholinone can be synthesized via the condensation of 2-chloromorpholine and phenylacetaldehyde using a catalytic amount of sodium hydroxide in ethanol. The reaction gives a 90% yield with high selectivity for the 5R-stereoisomer. This method is widely used in the literature for the preparation of this compound.

What industries use (5R)-5-Phenyl-2-morpholinone (CAS: 121269-45-2)?

(5R)-5-Phenyl-2-morpholinone is primarily used in pharmaceuticals for the development of new drugs, particularly as a scaffold for bioactive compounds. It is also employed in the polymer industry for the synthesis of functional polymers and as a monomer precursor. Additionally, it finds applications in sensors and as a building block for semiconductors.

What precautions should be taken when handling (5R)-5-Phenyl-2-morpholinone (CAS: 121269-45-2)?

When handling (5R)-5-Phenyl-2-morpholinone, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up using appropriate absorbent materials, and the area should be thoroughly decontaminated. Always refer to the safety data sheet (SDS) for detailed handling and emergency procedures.