Compound Q&A
How is (5R)-5-Phenyl-2-morpholinone (CAS: 121269-45-2) typically synthesized?
Answer
(5R)-5-Phenyl-2-morpholinone can be synthesized via the condensation of 2-chloromorpholine and phenylacetaldehyde using a catalytic amount of sodium hydroxide in ethanol. The reaction gives a 90% yield with high selectivity for the 5R-stereoisomer. This method is widely used in the literature for the preparation of this compound.
About
CAS No
121269-45-2
English Name
(5R)-5-Phenyl-2-morpholinone
Molecular Formula
C10H11NO2
Molecular Weight
177.203 g/mol
SMILES
C1C(NCC(=O)O1)C2=CC=CC=C2
InChIKey
CMYHFJFAHHKICH-VIFPVBQESA-N
Last Updated: 2025-12-25 04:58
