3-Iodotetrahydrofuran

Basic Information

View in Editor

CAS Number

121138-01-0

Molecular Formula

C4H7IO

Molecular Weight

198 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

SMILES

View in Editor

C1COCC1I

InChI

InChI=1S/C4H7IO/c5-4-1-2-6-3-4/h4H,1-3H2

InChIKey

BKIQORJIKOPRCG-UHFFFAOYSA-N

LogP

1.2103

Topological Polar Surface Area

9.23 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

46.8

Synonyms & References

English

3-Iodotetrahydrofuran
3-iodooxolane
3-IODO-TETRAHYDRO-FURAN
Furan, tetrahydro-3-iodo-
(R)-3-Iodotetrahydrofuran
3-iodanyloxolane
iodotetrahydrofuran
BKIQORJIKOPRCG-UHFFFAOYSA-N
BCP14190
SBB092235
RP08249
PB14773
AK170642
AB1011667
AB0080936
AM20080159
ST24042246
A804668
138I010
(3S)-3-iodotetrahydrofuran
3-iodotetrahydrofuran
J-512708
MFCD17015958
DB-061859
PB22839
EN300-211438
C4H7IO
SY111470
AKOS006311105
AS-41776
PB34863

MDL Number

MFCD09878873

Customs Code

2932190090

FAQ

What are the physical and chemical properties of 3-Iodotetrahydrofuran (CAS: 121138-01-0)?

3-Iodotetrahydrofuran (CAS: 121138-01-0) is a colorless to yellowish liquid with a molecular weight of 223.91 g/mol. It has a low melting point around -41°C and a boiling point of 68°C. The compound is slightly soluble in water butmiscible with many organic solvents. It is moderately reactive and can undergo substitution reactions, particularly with nucleophiles.

How is 3-Iodotetrahydrofuran (CAS: 121138-01-0) typically synthesized?

3-Iodotetrahydrofuran can be synthesized by treating iodomethane with tetrahydrofuran (THF) in the presence of a catalytic amount of base, such as potassium hydroxide. The reaction is typically carried out in an aprotic solvent. The selectivity and yield are high, with the product isolated by simple distillation.

What industries use 3-Iodotetrahydrofuran (CAS: 121138-01-0)?

3-Iodotetrahydrofuran (CAS: 121138-01-0) is primarily used in pharmaceuticals for the synthesis of various iodine-containing compounds. It also finds applications in the production of certain polymers and as a precursor in the manufacturing of sensors and semiconductors.

What precautions should be taken when handling 3-Iodotetrahydrofuran (CAS: 121138-01-0)?

When handling 3-Iodotetrahydrofuran (CAS: 121138-01-0), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using absorbent materials, and proper disposal methods should be followed. Always consult the Safety Data Sheet (SDS) for detailed safety guidelines.