3-Iodotetrahydrofuran(CAS: 121138-01-0)

3-Iodotetrahydrofuran (CAS: 121138-01-0) is a colorless to yellowish liquid with a molecular weight of 223.91 g/mol. It has a low melting point around -41°C and a boiling point of 68°C. The compound is slightly soluble in water butmiscible with many organic solvents. It is moderately reactive and can undergo substitution reactions, particularly with nucleophiles.

3-Iodotetrahydrofuran can be synthesized by treating iodomethane with tetrahydrofuran (THF) in the presence of a catalytic amount of base, such as potassium hydroxide. The reaction is typically carried out in an aprotic solvent. The selectivity and yield are high, with the product isolated by simple distillation.

3-Iodotetrahydrofuran (CAS: 121138-01-0) is primarily used in pharmaceuticals for the synthesis of various iodine-containing compounds. It also finds applications in the production of certain polymers and as a precursor in the manufacturing of sensors and semiconductors.

When handling 3-Iodotetrahydrofuran (CAS: 121138-01-0), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using absorbent materials, and proper disposal methods should be followed. Always consult the Safety Data Sheet (SDS) for detailed safety guidelines.