5-Chloro-2-oxo-3-(2-thienylcarbonyl)-1-indolinecarboxamide

Basic Information

View in Editor

CAS Number

120210-48-2

Molecular Formula

C14H9ClN2O3S

Molecular Weight

320.76 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

230° (dec)

Solubility

DMSO: soluble1mg/mL, clear (warmed)

SMILES

View in Editor

C1=CSC(=C1)C(=O)C2=C(N(C3=C2C=C(C=C3)Cl)C(=O)N)O

InChI

InChI=1S/C14H9ClN2O3S/c15-7-3-4-9-8(6-7)11(13(19)17(9)14(16)20)12(18)10-2-1-5-21-10/h1-6,11H,(H2,16,20)

InChIKey

IGPDWKCUDHIIRL-UHFFFAOYSA-N

LogP

3.2531000000000017

Topological Polar Surface Area

83.63 Å²

Hydrogen Bond Donor/Acceptor

3 / 5

Complexity

450

Safety Information

View Safety Information

GHS Hazard Pictograms

H302

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

Synonyms & References

English

[Z]-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide
TENIDAP [WHO-DD]
MS-24741
SR-01000883975-1
DTXSID9046104
5-chloro-2-hydroxy-3-(thiophene-2-carbonyl)indole-1-carboxamide
9K7CJ74ONH
CP-66,248
TENIDAP
CAS-120210-48-2
TENIDAP [INN]
CP 66,248
BDBM50331888
CHEMBL1097558
TENIDAP [MI]
SCHEMBL24922
SCHEMBL3751878
DB13481
5-Chloro-2-oxo-3-(thiophene-2-carbonyl)-2,3-dihydro-indole-1-carboxylic acid amide(tenidap)
NCGC00160352-01
(z)-5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1h-indole-1-carboxamide
(3Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide
NCGC00167784-01
Tenidapum [INN-Latin]
CS-0024729
HMS3413H21
5-Chloro-2-oxo-3-(thiophene-2-carbonyl)-2,3-dihydro-indole-1-carboxylic acid amide
(3Z)-5-chloro-3-[hydroxy(2-thienyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-1-carboxamide
Tenidap [USAN:INN:BAN]
HMS3677H21
AKOS000280742

MDL Number

MFCD00865996

FAQ

What are the physical and chemical properties of 5-Chloro-2-oxo-3-(2-thienylcarbonyl)-1-indolinecarboxamide (CAS: 120210-48-2)?

5-Chloro-2-oxo-3-(2-thienylcarbonyl)-1-indolinecarboxamide is a crystalline compound with a molecular weight of approximately 313.04 g/mol. It has a low solubility in water but is more soluble in organic solvents. The compound exhibits good stability under acidic conditions and moderate reactivity under basic conditions. It is a white or off-white crystalline solid with a characteristic odor.

How is 5-Chloro-2-oxo-3-(2-thienylcarbonyl)-1-indolinecarboxamide (CAS: 120210-48-2) typically synthesized?

5-Chloro-2-oxo-3-(2-thienylcarbonyl)-1-indolinecarboxamide is typically synthesized through a multi-step reaction involving the condensation of 2-thiophenecarbonyl chloride with 1-indoline-2,3-dione, followed by chlorination. The reaction is catalyzed by a Lewis acid such as aluminum chloride. The yield is around 75-85%, and the selectivity is high, making it a reliable synthesis method.

What industries use 5-Chloro-2-oxo-3-(2-thienylcarbonyl)-1-indolinecarboxamide (CAS: 120210-48-2)?

5-Chloro-2-oxo-3-(2-thienylcarbonyl)-1-indolinecarboxamide is used in the pharmaceutical industry for the development of certain drugs. It also finds applications in the polymer industry as a precursor for various polymer matrices. Additionally, it is used in the sensors and semiconductors industries for specific chemical sensing and electronic device applications.

What precautions should be taken when handling 5-Chloro-2-oxo-3-(2-thienylcarbonyl)-1-indolinecarboxamide (CAS: 120210-48-2)?

When handling 5-Chloro-2-oxo-3-(2-thienylcarbonyl)-1-indolinecarboxamide, it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be stored in a dry, well-ventilated area, away from direct sunlight and heat sources. In case of a spill, it should be cleaned up using appropriate methods, and the SDS (Safety Data Sheet) should be consulted for detailed guidance on handling and disposal.